Objective: To synthesise a series of quinazolinone clubbed pyrazole derivatives and evaluate for their antibacterial activity. Method: Various Quinazolinone clubbed Pyrazole derivative compounds were synthesized as per standard chemical procedure and characterized by physical and spectral analysis. The antimicrobial activities of all the synthesized compounds were evaluated separately for their...

Traditional medicine and ecological cues can both help to reveal bioactive natural compounds. Indigenous Australians have long used kino from trunks of the eucalypt tree, Corymbia citriodora, in traditional medicine. A closely related eucalypt, C. torelliana, produces a fruit resin with antimicrobial properties that is highly attractive to stingless bees. We tested the antimicrobial activity of...

The need for new antimicrobial agents with activity against Gram-positive organisms has become increasingly important because of emerging resistance. We compared the activity of a new b-lactam antimicrobial agent, RWJ-54428 (MC-02 479), with representatives of other classes of antimicrobial agents against 76 Staphylococcus aureus (including four glycopeptide- intermediate strains), 50 coagulase...

The in vitro antimicrobial activity of serial petroleum ether, chloroform and methanol extracts from leaves of Aegle mawmelos were investigated against bacterial and fungal species. All the extracts exhibited broad spectrum antimicrobial activity with zones of inhibition ranging from 10 to 22 mm against bacteria: Staphylococcus aureus, beta Streptococcus haemolyticus group A, Proteus mimrabilis...

       Antimicrobial activity of the polar and nonpolar extracts of the roots and aerial parts of Peucedanum ruthenicum M. Bieb., Johreniopsis seseloides (C. A. Mey.) Pimenov and Cervaria cervariifolia (C. A. Mey.) Pimenov were examined against gram-positive and gram-negative bacteria. The polar extracts of the roots and aerial parts displayed no activity against bact...

Some novel (phenyl-diazenyl)phenols (4a-m) were designed and synthesized to be evaluated for their antibacterial activity. Starting from an active previously-synthesized azobenzene chosen as lead compound, we introduced some modifications and optimization of the structure, in order to improve solubility and drug conveyance. Structures of all newly-synthesized compounds were confirmed by ¹H nucl...

Surface-associated marine bacteria are an interesting source of new secondary metabolites. The aim of this study was the isolation and identification of epiphytic bacteria from the marine brown alga, Bifurcaria bifurcata, and the evaluation of the antioxidant and antimicrobial activity of bacteria extracts. The identification of epiphytic bacteria was determined by 16S rRNA gene sequencing. Bac...

Plants are rich source of natural products used for centuries to cure various the plant-derived medicines are based upon the premise that they contain natural substances that can promote health and alleviate illness. Silver NPs represent material, which can be used as a potential antibacterial agent in medical applications and different commercial products due to its biological activity. Recent...

The aqueous, methanolic and phenolic extracts of Rubus ulmifolius leaves were studied and tested for their antimicrobial and antifungi activity against some clinical bacteria .Than the acute toxicity was evaluated. The results showed that the phenolic extract was the most active of staphylococcus aureus with a maximum zone of inhibition 7-12mm. All the other bacteria and fungi showed no signifi...