In this paper, we consider the two-dimensional rectangular strip packing problem, in the case where there is a perfect packing; that is, there is no wasted space. One can think of the problem as a jigsaw puzzle with oriented rectangular pieces. Although this comprises a quite special case for strip packing, we have found it useful as a subroutine in related work. We demonstrate a simple pruning...

Spondyloarthropathies are inflammatory diseases closely associated with human leukocyte antigen (HLA)-B27 by unknown mechanisms. One of these diseases is reactive arthritis (ReA), which is typically triggered by Gram-negative bacteria, which have lipopolysaccharide as an integral component of their outer membrane. Several findings in vivo and in vitro obtained from patients with ReA and from di...

This paper presents Colt, a system designed to aid in the development of applications that support close collaboration between two or more users. The Colt system is comprised of three parts: a design methodology, a software toolkit, and visualization and analysis tools. The software toolkit includes computational objects that support simultaneous manipulations from multiple users. This paper de...

In eukaryotic cell division, the kinetochore mediates chromosome attachment to spindle microtubules and acts as a scaffold for signaling pathways, ensuring the accuracy of chromosome segregation. The architecture of the kinetochore underlies its function in mitosis. In this issue, Hornung et al. (2014. J. Cell Biol. http://dx.doi.org/201403081) identify an unexpected linkage between the inner a...

A fter his encounter with the Atlantic rainforest of Brazil, Charles Darwin observed that “the land is one great, wild, untidy, luxuriant hothouse, made by Nature for herself ” (1). Increasing knowledge of the forest fauna over the past 30 years has only underscored Darwin’s point: 978 species of beetles from six trees in Venezuela, 160 species of grasshoppers in 60 trees in Amazonia, 218 speci...

Objective: Create a visual mobile end user development framework, named Puzzle, which allows end users without IT background to create, modify and execute applications, and provides support for interaction with smart things, phone functions and web services. Methods: Design of an intuitive visual metaphor and associated interaction techniques for supporting end user development in mobile device...

In this study we investigated the use of gaze and pointing gestures in scenarios where a human has to follow the instructions of a humanoid robot. Our objective was to analyze the performance of a human participant, that solves an abstract jigsaw puzzle with the help of our robot instructor, in different grounding scenarios with varying difficulty. Furthermore we investigated how the attitude t...