abstract   background: sacroiliac joint (sij) dysfunction is a widely known but poorly defined cause of low back pain. to our knowledge, few published studies have been conducted to evaluate systematically the prevalence and significance of concomitant sacroiliac joint dysfunction in patients with herniated lumbar discs. as concomitant sij dysfunction in low back pain patients is likely to resp...

The polarity protein PAR-1 plays an essential role in many cellular contexts, including embryogenesis, asymmetric cell division, directional migration, and epithelial morphogenesis. Despite its known importance in different cellular processes, the role of PAR-1 in neuronal morphogenesis is less well understood. In particular, its role in the morphogenesis of dendritic spines, which are sites of...

Abstract Leigh syndrome (LS) is a severe manifestation of mitochondrial disease in children and currently incurable. The lack effective models hampers our understanding the mechanisms underlying neuronal pathology LS. Using patient-derived induced pluripotent stem cells CRISPR/Cas9 engineering, we developed human model LS caused by mutations complex IV assembly gene SURF1 . Single-cell RNA-sequ...

Branching morphogenesis of mouse salivary gland has been studied with organ-culture system. We developed a novel transfilter culture system for analyzing branching morphogenesis of the salivary epithelium. The submandibular salivary epithelium from early 13-day mouse fetus, clotted with Matrigel and separated from the mesenchyme by membrane filter, showed extensive growth and branching morphoge...

The final form of the polar lobe and lateral wings of developing semicells of M. rotata results from combined action of three growth processes: tip growth, branching and lobe broadening. Tip growth unaccompanied by branching or broadening occurs during normal development in M. radiata, but is observed only under abnormal conditions (e.g. raised temperature) in M. rotata. When branching and broa...

objective(s) the aim of this study was to investigate glycoconjugates distribution patterns as well as their changes during the course of pituitary portal vasculogenesis and angiogenesis. materials and methods formalin fixed paraffin sections of 10 to 20 days of sprague dawly rat fetuses were processed for histochemical studies using four different horseradish peroxidase (hrp) conjugated lectin...