the sex cord-like variant of endometrioid carcinoma is a rare subtype with a close histological resemblance to the sex cord-stromal tumor of the ovaries, in particular the sertoli cell tumor. however, very few cases of the granulosa cell tumor-like variant have been reported since it is commonly misdiagnosed as a granulose cell tumor. immunohistochemistry is useful in the diagnosis of these tum...

Reninoma is a tumor of the renal juxtaglomerular cell apparatus that causes hypertension and hypokalemia because of hypersecretion of renin. We present a case of a 29-year-old female patient with reninoma and concomitant variant angina. The patient had uncontrolled hypertension and elevated plasma renin activity and aldosterone levels. Imaging studies revealed a mass in the left kidney, which w...

IN A SYMPOSIUM devoted to angiotensin, it is appropriate to consider briefly the juxtaglomerular apparatus. Angiotensin makes its appearance in the body as a direct result of the proteolytic action of renin, and there is considerable evidence to support the hypothesis that all the renin in a kidney comes from the juxtaalomerular apparatus. Before reviewing this evidence, the anatomy of the juxt...

In our previous studies on the granulation of juxtaglomerular cells, we were impressed with several experiments in which a kidney was perfused with blood at a high pressure and had a striking decrease in the juxtaglomerular granulation (1). Conversely, in other situations where the pressure of the blood perfusing the kidney was reduced, the juxtaglomerular granulation tended to increase (1). Th...

desmoplastic small round cell tumor is a rare malignant tumor that occurs primarily in young males. here, a case of small round cell tumor in an adult male successfully treated with a curative concurrent chemoradiotherapy is presented. a 58-year-old man had an intrapelvic tumor. surgical resection was attempted, but the tumor was unresectable. needle biopsy was performed and the diagnosis was s...

metastatic lesions represent 1-8% of all malignant tumors of the mouth and jaws, which are regarded as rare sites of metastases from different primary tumors. metastases in mouth soft tissue are also rare, and within these it is on the gums where they more frequently occur. primary tumors which metastasize to the mouth are most commonly: lung, breast, and kidney. clear cell carcinoma is the mos...

This study aimed to examine the direct influence of native endothelium derived relaxing factor (EDRF) on renin secretion. To this end isolated mouse renal juxtaglomerular cells were cocultured with bovine aortic endothelial cells which produced and released significant amounts of EDRF as assayed by guanylate cyclase activities which were measured separately in endothelial and juxtaglomerular ce...

A stable nitroxide 4-hydroxy-2,2,6,6-tetramethylpiperidine-N-osyl (Tempol) is widely used as an antioxidant in vitro and in vivo. In this study, we investigated the effects of Tempol on the growth of As4.1 juxtaglomerular cells in relation to cell cycle and cell death. Tempol dose-dependently decreased the growth of As4.1 cells with an IC50 of ~1 ...

central granular cell odontogenic tumor) cgcot) of the jaw is an exceedingly rare benign odontogenic neoplasm with 35 reported cases in the literature. among these, very few studies have focused on the cone-beam ct features of cgcot. here, we report a case of an asymptomatic cgcot in a 16-year-old girl and focus on the cone-beam ct features. only 36 cases of this lesion, including this one, hav...

congenital granular cell tumor (cgct) is a unique benign tumor of soft tissue in newborns, which usually occurs on the anterior alveolar mucosa of the jaws. it is 8 to 10 times more prevalent in females than males. we present a case report of a 3-month-old female infant, who had a solitary mass on the anterior mandibular alveolar ridge. the lesion, which was histologically a congenital granular...