Nizatidine is a gastroprotective drug with short biological half-life and narrow absorption window. This study aimed at developing floating tablets of nizatidine using various HPMC viscosity grades, namely K4M, E4M, K15 K200M. Directly compressed revealed an excellent uniformity in hardness, thickness weight was evenly distributed within the matrix tablets. Buoyancy lag time as low 18–38 s, rem...