one of the causes of neonatal hyperbilirubinemia is increased reabsorption of bilirubin from meconium in the gastrointestinal tract. this occurs when the conjugated bilirubin which is excreted into the colon is 'unconjugated by beta glucuronidase activity, present in the neonatal intestine, which hydrolyzes bilirubin diglucuronide into unconjugated bilirubin, which subsequently is reabsorb...

ARIAS, IRWIN M., LOIS JOHNSON, AND SONIA WOLFSON. Biliary excretion of injected conjugated and unconjugated bilirubin by normal and Gunn rats. Am. J. Physiol. 200(5) : I 091-1094. I 961. -Conjugated and unconjugated bilirubin were injected intravenously at different times into normal rats and homozygous, jaundiced Gunn rats. As was expected, Gunn rats did not excrete injected unconjugated bilir...

Hepatic biotransformation of bilirubin to the hydrophilic species bilirubin mono- (BMG) and diglucuronide (BDG) by microsomal bilirubin UDP-glucuronosyl-transferase (GT) is a prerequisite for its physiologic excretion into bile. The reaction mechanism of bilirubin-GT and the access of bilirubin and BMG (the intermediate substrate) to the active site of bilirubin-GT are undefined. Highly purifie...

Many cities in the Global South are structurally different from Northern, particularly American, on which much of urban sociology’s conceptual apparatus has been based. Thus, depicting them terms a standard vocabulary risks imposing an inappropriate way seeing. We need that is able to accommodate their experience. This special issue contributes work building vocabulary. select five keywords soc...

OBJECTIVE To compare transcutaneous bilirubin with total serum bilirubin in preterm neonates after initiation of phototherapy. METHODS Jaundice was assessed in 30 preterm neonates with transcutaneous bilirubin and total serum bilirubin before initiation of phototherapy and at 12 hr after initiation of phototherapy. A photo-occlusive patch was applied over the sternum. RESULTS Transcutaneous...

Neonatal jaundice can be best understood as a balance between the production and elimination of bilirubin, with a multitude of factors and conditions affecting each of these processes. When an imbalance results because of an increase in circulating bilirubin (or the bilirubin load) to significantly high levels (severe hyperbilirubinemia), it may cause permanent neurologic sequelae (kernicterus)...

Increased serum levels of unconjugated bilirubin are associated with the development of brain damage in newborns. In current clinical settings, there are no methods for directly determining serum levels of unconjugated bilirubin. UnaG, a fluorescent protein from Japanese eel muscle that specifically binds to unconjugated bilirubin was used in this study. Linear regression analysis was carried o...