We describe a case report where buprenorphine was successfully used for the management of kratom ( Mitragyna speciosa) dependency during Covid-19 pandemic in specialist community substance misuse treatment service. The individual had notable iatrogenic on oral over counter and prescribed opioid medication. She resorted to using as ‘tea’ self-detoxify before getting into difficulty. Upon present...

This work introduces three eco-friendly UV spectrophotometric methods for the simultaneous estimation of Paracetamol, Aceclofenac and Eperisone Hydrochloride in pharmaceutical tablet formulation. The procedures employed were equation method multivariate chemometric with phosphate buffer pH 7.80 as diluent. encompasses absorbance measurement at different wavelengths (λmax drugs). It exhibits lin...

Aim: In present Pharmaceutical trend, natural excipients are gaining more importance because of their availability, safety, performance, and cost. The work aimed at extraction the mucilage from stem Musa paradisiaca (banana) evaluation extracted for its binding disintegrating properties with Paracetamol as a model drug.
 Methodology: was by aqueous method followed precipitation evaluated v...

This randomized, double-blind, double-dummy, multicenter trial compared efficacy and safety of tramadol HCL 37.5 mg/paracetamol 325 mg combination tablet with tramadol HCL 50 mg capsule in the treatment of postoperative pain following ambulatory hand surgery with iv regional anesthesia. Patients received trial medication at admission, immediately after surgery, and every 6 hours after discharge...

Aim: To study the comparative hepatoprotective effect of Virgin Coconut Oil (VCO) and Neem (Azadirachta indica) leaf extract in acetaminophen (Paracetamol) induced liver toxicity. Methods: About 60 mixed population rats (male/female) Wistar Sprague-Dawley species were randomly selected for proposed are segregated into four equal groups. Every group contains 15 animal subjects. Group A was contr...

δ-mannitol is a metastable polymorph of mannitol, known for its superior tableting properties. However, there no easy, reproducible and scalable production method δ-mannitol. It was evaluated whether could be formed via co-spray drying with an API exhibiting tabletability issues, to improve the in one-step process prior compaction. Aqueous suspensions paracetamol β-mannitol were dried. Raman sp...

Ahead of Print article withdrawn by publisher AIM: Intravenous regional anesthesia (IVRA) is frequently used in patients who will undergo upper extremity surgical operations for its ease of use, rapid effectiveness and short hospitalization period. Different drug combinations have been used to overcome some systemic adverse effects and to increase the postoperative analgesic effectiveness. In o...

A system using energy-dispersive X-ray diffraction (EDXRD) has been developed and tested using multivariate calibration for the quantitative analysis of tablet-form mixtures of common pharmaceutical ingredients. A principal advantage of EDXRD over the more traditional and common angular dispersive X-ray diffraction technique (ADXRD) is the potential of EDXRD to analyse tablets within their pack...

Seed starch (16.0%w/w) obtained from Abelmoschus moschatus Linn. (Malvaceae) was employed as a disintegrant to paracetamol tablets at concentrations of 2.5-10.0% w/w. The granules prepared by wet granulation technique were evaluated for percentage of fines and flow properties. Tablet properties including thickness, content uniformity, average weight and weight variation, hardness, friability, d...