In two-kidney, one clip (2K1C) renovascular hypertension, blood flow is reduced to the clipped but not to the nonclipped kidney, despite elevated angiotensin II. To determine possible interactions between endothelium-derived nitric oxide and angiotensin, we studied bilateral renal blood flow using radioactive microspheres in anesthetized 2K1C hypertensive rats 4 weeks after clipping. We studied...

BACKGROUND To assess the renal growth and function of neonates during infancy in relation to birth weight and gestational age. METHODS A longitudinal study was conducted at a tertiary hospital in South India from June 2010 to August 2014. Low birth weight neonates (LBW) were further sub-classified based on gestational age and compared with normal birth weight (NBW) full term neonates at birth...

Several groups including ours have demonstrated cardiac hyperplasia in neonates from genetically hypertensive rat strains. We have shown that similar problems exist in the kidney as well. More recently, we found that excessive heart and kidney weight is neonatally related to inhibition of apoptosis. Using recombinant inbred strains derived from a reciprocal cross between Brown Norway and sponta...

The aim of present study was to investigate the antioxidant enzymes activity and oxidative status of Cinnamon and Garlic – treated rats. 12 male Wistar Albino rats were randomly divided into 3 groups (n=4). Group I: Control rats received distilled water; Group II: Received aqueous extract of Cinnamon (10 mg / kg b.w.) orally for 13 consecutive days; Group III: Received aqueous extract of Garlic...

The study was designed to investigates the therapeutic roles of Crataegus azarolus Var. aronia L. (C. aronia) in kidney stone treatment male albino rats’ model induced by ethylene glycol (EG). Twenty animals weighing 220–270 g were divided into control group which set as A, while rats B and C groups, received 1% EG for 28 days, but also C. (7.5g plant/100ml water 10g plant/ 90 diet) from day 15...

Adaptive growth responses of the embryo and fetus to nutritional restraint are important in ensuring early survival, but they are implicated in the programming of hypertension. It has been demonstrated that kidney growth and nephrogenesis are each regulated by intrarenal factors, including the insulin-like growth factors, glucocorticoids, and the renin-angiotensin system. Therefore, we have inv...

OBJECTIVE The association of low birth weight (LBW) with adult onset diseases like hypertension is suggested to be partially mediated by a low number of nephrons at birth. Studies have established a relation between LBW and renal volume as the latter is a surrogate marker of total nephron number. Most such studies have considered birth weight or gestational age as separate independent predictor...

LOTSPEICH, WILLIAM D. Renal hypertrophy in metabolic acidosis and its relation to ammonia excretion. Am. J. Physiol. 208(6) : I 135-1142. 1 g65.-The chronic ingestion of NH&l causes a true growth of the rat kidney. This involves a symmetrical increase in wet weight, dry weight, and nitrogen of the kidney tissue. Total DNA and RNA are also elevated, indicating that both cell numbers and cell siz...

Obesity is associated with the early onset of glomerulomegaly, hemodynamic changes of a hyperfiltering kidney, and increased albuminuria, which are potentially reversible with weight loss. However, pathologic lesions of focal segmental glomerulosclerosis develop in experimental models of sustained obesity, and are observed in morbidly obese humans presenting with massive proteinuria. In additio...