Accepted 16 February 2018 DesCripTion A 2-month-old full-term male infant presented with worsening tachypnoea and a rapidly enlarging, smooth-topped, infiltrative, bronze-yellow nodule with overlying telangiectasias on the mid-sternum (figure 1A). CT imaging demonstrated multiple pulmonary nodules, and enhancing extradural masses compressing the L4–L5 vertebral neural foramina. Immunohistochemi...

Faithful chromosome segregation during cell division requires accurate mitotic spindle formation. As mitosis occurs rapidly within the cycle, proteins involved in assembly undergo rapid changes, including their interactions with other proteins. The proper localization of HURP protein on kinetochore fibers, close proximity to chromosomes, is crucial for ensuring congression and chromosomes. In t...