Objective. In recent years, public health experts have concluded that the impact of osteoarthritis is equal in magnitude to that of cardiovascular disease. Osteoarthritis of the knee is prevalent in the elderly population; however, there are currently no effective treatments for this condition. In this study, we investigated the efficacy of "meridian-sinew release," a newly developed technique ...

Background Over the past decade, phenotypes have been used to help categorize knee osteoarthritis patients relative to being subject to disease, disease progression, and treatment response. A review of potential phenotype selection is now appropriate. The appeal of using phenotypes is that they most rely on simple physical examination, clinically routine imaging, and demographics. The purpose o...

BACKGROUND Osteopetrosis is an uncommon, inherited disease, characterized by osteosclerosis, obliteration of the medullary canal, calcified cartilage and brittle bone due to impaired osteoclast resorption. Osteoarthritis is common in patients with osteopetrosis. If the patient has pain and dysfunction, total joint arthroplasty is often the treatment of choice but presents many intraoperative an...

Introduction. Endoprosthetics is currently most common method of the treatment of advanced osteoarthritis, including knee joint osteoarthritis. Its main goal is to restore patients functional independence in activities of daily living through reducing pain and disability. Objective. The aim of this study was functional assessment of the patients after total knee replacement (TKR) considering su...

PREFACE The present thesis is based on three papers listed below (referred to by roman numerals in the text). The original papers are attached. The studies have all been carried out at The Parker Institute Impulse-forces during walking are not increased in patients with knee osteoarthritis. Increased joint loads during walking – A consequence of pain relief in knee osteoarthritis.

OBJECTIVE(S) Osteoarthritis (OA) or degenerative joint disease is the commonest form of arthritis and can lead to joint pain, decrease in joint's range of motion, loss of function, and ultimately disability. Exercise is considered as one of the non-pharmacological treatments of OA. But the effects of exercise on knee joint cartilage remain ambiguous. The aim of the present study was to investig...

BACKGROUND Osteoarthritis is a disabling musculoskeletal disease with no definite treatment. This study compared the effect of Platelet-rich plasma (PRP) and Transcutaneous Electrical Nerve Stimulation (TENS) plus exercise in the treatment of patients with knee joint osteoarthritis. METHODS 54 eligible patients with knee osteoarthritis were randomly allocated into two groups. (IRCT20121106113...

BACKGROUND Adipokines are related to knee osteoarthritis, but their exact role is not well known. The aim of this study was to evaluate the association between adipokines in synovial fluid and clinical severity in patients with knee osteoarthritis with joint effusion. METHODS Cross-sectional study with systematic inclusion of female patients with symptomatic primary knee osteoarthritis with u...