A completion via Frink ideals is used to define a convex powerdomain of an arbitrary continuous lattice as a continuous lattice. The powerdomain operator is a functor in the category of continuous lattices and continuous inf-preserving maps and preserves projective limits and surjectivity of morphisms; hence one can solve domain equations in which it occurs. Analogous results hold for algebraic...

ADAMTS13 is a multidomain protease that limits platelet thrombogenesis through the cleavage of von Willebrand factor (VWF). We previously identified 2 types of mouse Adamts13 gene: the 129/Sv-strain Adamts13 gene encodes the long-form ADAMTS13 having the same domains as human ADAMTS13, whereas the C57BL/6-strain Adamts13 gene encodes the short-form ADAMTS13 lacking the distal C-terminal domains...

We investigate the properties of the Ising-Glauber model on a periodic cubic lattice of linear dimension L after a quench to zero temperature. The resulting evolution is extremely slow, with long periods of wandering on constant energy plateaus, punctuated by occasional energy-decreasing spin-flip events. The characteristic time scale τ for this relaxation grows exponentially with the system si...

The Bergman projection on a general bounded, smooth pseudoconvex domain in two complex variables need not be globally regular, that is, need not preserve the class of all functions that are smooth up to the boundary. In this article the construction of the worm domains is reviewed, with emphasis on those features relevant to their role as counterexamples to global regularity. Prior results, and...

We study solutions to Lu=f in ??Rn, being L the generator of any, possibly non-symmetric, stable Lévy process. On one hand, we regularity ?, u=0 ?c, C1,? domains ?. show that u satisfy u/d??C??(??), where d is distance ??, and ?=?(L,?) an explicit exponent depends on Fourier symbol operator unit normal ? boundary ??. other establish new integration by parts identities half spaces for such opera...

The availability of stable human antibody reagents would be of considerable advantage for research, diagnostic, and therapeutic applications. Unfortunately, antibody variable heavy and light domains (V(H) and V(L)) that mediate the interaction with antigen have the propensity to aggregate. Increasing their aggregation resistance in a general manner has proven to be a difficult and persistent pr...

Regulation and evolution of dinoflagellate luciferases are of particular interest since the enzyme is structurally unique and bioluminescence is under circadian control. In this study, three new members of the dinoflagellate luciferase gene family were identified and characterized from Pyrocystis lunula. These genes, lcfA, lcfB, and lcfC, also exhibit the unusual structure and organization prev...

The release of enveloped viruses from infected cells often requires a virally encoded activity, termed a late-budding domain (L domain), encoded by essential PTAP, PPXY, or YPDL sequence motifs. PTAP-type L domains recruit one of three endosomal sorting complexes required for transport (ESCRT-I). However, subsequent events in viral budding are poorly defined, and neither YPDL nor PPXY-type L do...

The mechanism by which nuclear and cytoplasmic filaments are sorted in vivo was studied by examining which lamin sequences are required to target an otherwise cytoplasmic IF protein, the small neurofilament subunit (NF-L), to the nuclear lamina. By swapping corresponding domains between NF-L and lamin A, nuclear envelope targeting of NF-L was shown to require the presence of the "head" domain, ...