s | 81 University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 110–799, Republic of Korea c Institute of Human Behavioral Medicine, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 110–799, Republic of Korea d Department of Psychiatry, Maeumsarang Hospital, Wanju, Jeollabuk-do, Republic of Korea *Corresponding author: Ung Gu Kang, M.D., Ph. D. Department of...

Retrotransposons are highly prevalent in mammalian genomes due to their ability to amplify in pluripotent cells or developing germ cells. Host mechanisms that silence retrotransposons in germ cells and pluripotent cells are important for limiting the accumulation of the repetitive elements in the genome during evolution. However, although silencing of selected individual retrotransposons can be...

Retrotransposon sequences are positioned throughout the genome of almost every eukaryote that has been sequenced. As mobilization of these elements can have detrimental effects on the transcriptional regulation and stability of an organism's genome, most organisms have evolved mechanisms to repress their movement. Here, we identify a novel role for the Drosophila melanogaster Condensin II subun...

s | 81 University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 110–799, Republic of Korea c Institute of Human Behavioral Medicine, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 110–799, Republic of Korea d Department of Psychiatry, Maeumsarang Hospital, Wanju, Jeollabuk-do, Republic of Korea *Corresponding author: Ung Gu Kang, M.D., Ph. D. Department of...

Abstract. Fatmawati Y, Setiawan AB, Purwantoro A, Respatie DW, Teo CH. 2021. Analysis of genetic variability in F2 interspecific hybrids mung bean (Vigna radiata) using inter-retrotransposon amplified polymorphism marker system. Biodiversitas 22: 4880-4889. Mung radiata L. Wilczek) categorized as one the pivotal annual crops Vigna genera is commonly cultivated rotation with cereal during drough...

Investigating Genetic Diversity and Relationships in some Henbane (Hyoscyamus spp.) Populations Based on Polymorphisms Resulting from Retrotransposon Insertion

The role of plant tyrosyl-DNA phosphodiesterase 1α in genome stability is studied using a Medicago truncatula MtTdp1α-depleted line. Lack of MtTdp1α results in a 39% reduction of methylated cytosines as compared to control. RNA-Seq analyses revealed that 11 DNA transposons and 22 retrotransposons were differentially expressed in the Tdp1α-2a line. Among them all, DNA transposons (MuDR, hAT, DNA...

APOBEC3s (A3s) are single-stranded DNA cytosine deaminases that provide innate immune defences against retroviruses and mobile elements. A3s are specific to eutherian mammals because no direct homologs exist at the syntenic genomic locus in metatherian (marsupial) or prototherian (monotreme) mammals. However, the A3s in these species have the likely evolutionary precursors, the antibody gene de...

Two new short retroposon families (SINEs) have been found in the genome of springhare Pedetes capensis (Rodentia). One of them, Ped-1, originated from 5S rRNA, while the other one, Ped-2, originated from tRNA-derived SINE ID. In contrast to most currently active mammalian SINEs mobilized by L1 long retrotransposon (LINE), Ped-1 and Ped-2 are mobilized by Bov-B, a LINE family of the widely distr...

There is an increased global outbreak of diseases caused by coronaviruses affecting respiratory tracts birds and mammals. Recent dangerous are MERS-CoV, SARS-CoV, SARS-CoV-2, causing illness even failure several organs. However, profound impact coronavirus on host cells remains elusive. In this study, we analyzed transcriptome SARS-CoV-2 infected human lung-derived cells, observed that infectio...