The molecular events that lead to the onset of labor in humans and in other mammalian species remain unclear. We propose that a decline in coactivators containing histone acetylase activity in myometrium may contribute to the onset of labor by impairing the function of the progesterone-progesterone receptor (PR) complex. As assessed by semiquantitative and real-time RT-PCR, immunohistochemistry...

Fetal membranes usually rupture during the process of labor. Premature fetal membrane rupture occurs not infrequently and is associated with significant fetal and maternal morbidity. The mechanisms of normal and pathologic fetal membrane rupture are not well understood. We have examined structural and biochemical changes in the rat amnion as labor approaches in order to characterize this proces...

Health technology The use of nevirapine prophylaxis to prevent mother-to-child transmission of the human immunodeficiency virus (HIV). Nevirapine prophylaxis consisted of a single dose to each mother and infant consistent with the HIVNET-012 trial, where mothers who consented to HIV testing and tested positive were offered nevirapine to them and their offspring. The mother was instructed to tak...

Real wage growth in the UK labour market, since around 2003, has slowed down and stagnated. In this paper, we document the nature of real wage changes across the wage distribution over the last three decades, showing that the recent period of stagnant real wage growth represents a distinct break of trend that pre-dates the onset of recession. We explore whether unemployment has become a stronge...

The aims and objectives of this study was to evaluate foetal health in high risk pregnancy with modified B.P.P., to record the perinatal outcome, to evaluate efficacy of modified B.P.P. in predicting perinatal outcome in high risk pregnancy. In this study 110 admitted cases having one or more high risk factors were studied. Modified B.P.P., N.S.T. and C.T.G. was done. Only the last antenatal te...

Gross, Gil, Takuji Imamura, Sherri K. Vogt, David F. Wozniak, D. Michael Nelson, Yoel Sadovsky, and Louis J. Muglia. Inhibition of cyclooxygenase-2 prevents inflammation-mediated preterm labor in the mouse. Am J Physiol Regulatory Integrative Comp Physiol 278: R1415–R1423, 2000.—Prostaglandins (PGs) have proven important during parturition, but inhibition of PG production treating preterm labor...

It is presently being debated whether the partograph is a useful tool for labor supervision and, if useful, where should the action line be located between 2, 3 or 4 h to improve the fetomaternal outcome. This review adduces facts to show that this debate is because there is a poor understanding of the essence and purpose of the partograph. The partograph is a form on which labor observations a...

OBJECTIVE To determine coital incidence at term and to estimate its effect on labor onset and mode of delivery. METHODS Healthy women with uncomplicated pregnancies and established gestational age were recruited to keep a diary of coital activity from 36 weeks of gestation until birth and to answer a short questionnaire. Two hundred women with complete coital diaries were available for analys...

Labor induction is defined as the artificial onset of labor for the purpose of vaginal birth. Cesarean section is one of the potential risk of labor induction as it occur in about 20% of the inductions. A ripe cervix (soft and distensible) is needed for a successful labor. During the ripening cervical tissues experience micro structural changes: collagen becomes disorganized and water content i...

IMPORTANCE One in 88 children in the United States is diagnosed as having autism spectrum disorder. Significant interest centers on understanding the environmental factors that may contribute to autism risk. OBJECTIVE To examine whether induced (stimulating uterine contractions prior to the onset of spontaneous labor) and/or augmented (increasing the strength, duration, or frequency of uterin...