Aim: The present study was conducted to record the association of extended spectrum β-lactamases (ESBLs) producing enteric bacteria with diarrhea of poultry birds in Mizoram, India. Materials and Methods: Fecal samples were collected from poultry birds with the history of diarrhea from different parts of Mizoram. Samples were processed for isolation and identification of Escherichia coli, Salmo...

SHV extended-spectrum beta-lactamases (ESBLs) arise through single amino acid substitutions in the parental enzyme, SHV-1. In order to evaluate the effect of genetic dissimilarities around the structural gene on MICs, we had previously devised an isogenic system of strains. Here, we present an extended version of the system that now allows assessment of all major types of SHV beta-lactamases as...

Antimicrobial-resistant organisms are an emerging global health problem that will likely evolve into one of the most significant challenges facing medical practice.1 Infections with resistant organisms lead to increased patient morbidity as a result of antibiotic treatment failures. Costs incurred by prolonged hospital stays are only a small portion of the additional expenses associated with th...

Within the ESBL family the most common genes are temoneira (blaTEM) and sulfhydryl variable (blaSHV) with increasing reports of cefotaximase (blaCTX-M) [4]. The blaSHV and the blaTEM subgroups arise from mutational changes due to point mutations in the genes resulting in subtypes. Examples include blaSHV which differs from blaSHV-1 due to a single mutation of an amino acid from glycine to serin...

INTRODUCTION .......................................................................................................................................................161 MECHANISM OF ACTION OF -LACTAM ANTIBIOTICS .............................................................................161 RESISTANCE TO -LACTAM ANTIBIOTICS ..........................................................................

Objective: In addition to assessing the phenotypic development of biofilms and beta-lactamases, in current study, Pseudomonas aeruginosa isolates from intensive care units (ICU) patients with prevalent drug resistance are being evaluated. Methods: Standard CLSI recommended protocols were utilized detect beta-lactamases such as extended-spectrum β-lactamases (ESBL), metallo beta-lactamase (MBL),...

Antibiotic resistance among Gram-negative rods (GNRs) causing hospital-acquired infections poses a threat, particularly to intensive care unit (ICU) patients. This study was undertaken in order to achieve the following: to detect the frequency of GNRs isolated from coronary and surgical ICUs at the Institute of Cardiology, Istanbul University, between January 2000-December 2002; to compare the ...

BACKGROUND There is a need for new oral agents active against extended-spectrum beta-lactamase (ESBL) producers, as these increasingly cause community-onset infections. We therefore evaluated faropenem, a penem in Phase III development, against recently collected oxyimino-cephalosporin-resistant bacteria. METHODS We tested 847 consecutive cephalosporin-resistant Enterobacteriaceae collected a...

BACKGROUND & OBJECTIVES Non-fermenting Gram-negative bacilli (NFGNB) including Pseudomonas aeruginosa and Acinetobacter baumannii have been implicated in a variety of infections, particularly in the Intensive Care Units (ICUs). This study was aimed to overview the burden of multidrug-resistant NFGNB causing infections in ICU and also to assess the occurrence of extended-spectrum beta-lactamases...

This study was designed to investigate the prevalence of metallo-β-lactamases (MBL) and extended-spectrum β -lactamases (ESBL) in P. aeruginosa isolates collected from two different hospitals in Cairo, Egypt. Antibiotic susceptibility testing and phenotypic screening for ESBLs and MBLs were performed on 122 P. aeruginosa isolates collected in the period from January 2011 to March 2012. MICs wer...