Many of the circulatory and metabolic effects of epinephrine remain in doubt despite (or perhaps, to some extent, owing to) the wide variety of experimental techniques used to examine them. There is agreement that when epinephrine is given intravenously to man, blood glucose concentration increases due to hepatic glycogenolysis (1), blood lactate concentration rises due largely to glycogenolysi...

Walker, Hazel (University of Georgia, Athens), and R. G. Eagon. Lactic dehydrogenases of Pseudomonas natriegens. J. Bacteriol. 88:25-30. 1964.-Lactic dehydrogenases specific for d- and l-lactate were demonstrated in Pseudomonas natriegens. The l-lactic dehydrogenase showed considerable heat stability, and 40% of the activity remained in extracts after heating at 60 C for 10 min. An essential th...

AIMS We previously reported that vasodilatation was common in pediatric septic shock, regardless of whether they were warm or cold, providing a rationale for early norepinephrine (NE) to increase venous return (VR) and arterial tone. Our primary aim was to evaluate the effect of smaller fluid bolus plus early-NE versus the American College of Critical Care Medicine (ACCM) approach to more liber...

OBJECTIVES To review early surgical outcomes in a contemporary series of adults with congenital heart disease (CHD) undergoing cardiac operations at the University of Michigan, and to investigate possible preoperative and intraoperative risk factors for morbidity and mortality. METHODS A retrospective medical record review was performed for all patients > or =18 years of age who underwent ope...

INTRODUCTION Pulmonary oedema and impairment of oxygenation are reported as common consequences of haemorrhagic shock and resuscitation (HSR). Surprisingly, there is little information in the literature examining differences in crystalloid type during the early phase of HSR regarding the development of pulmonary oedema, the impact on oxygenation and the haemodynamic response. These experiments ...

BACKGROUND Intestinal obstructions/pseudo-obstruction of the small/large bowel are frequent conditions but their management could be challenging. Moreover, a general agreement in this field is currently lacking, thus SICUT Society designed a consensus study aimed to define their optimal workout. METHODS The Delphi methodology was used to reach consensus among 47 Italian surgical experts in tw...

Cardiac surgery performed with cardiopulmonary bypass (CPB) may be complicated by hypotension due to low systemic vascular resistance (SVR). Often in those cases, hypotension is resistant to pressor catecholamines. We report six cases of norepinephrine-resistant postcardiotomy hypotension, treated by terlipressin (TP), a potent vasopressor agent. Between May 2007 and May 2008, we treated six pa...

INTRODUCTION Blood lactate measurements can be used as an indicator of hemodynamic impairment and relate to mortality in various forms of shock. Little is known at the moment concerning the clinical correlates of systemic lactate in patients with ST-segment elevation myocardial infarction (STEMI). METHODS To assess the relation of systemic arterial lactate levels in STEMI patients with clinic...

As a strong proponent of transradial cardiac catheterization who long ago stopped using the Allen’s test, I read the study by Greenwood et al. (1) with great interest. As correctly pointed out in the report, no published study of hand ischemia has been reported after transradial procedures nor after surgical harvest related to the state of the Allen’s test. This suggests that the hand circulati...