The Effects of Vitamin B6 on the Systolic Blood Pressure of Rats in Various Animal Models of Hypertension, Lal et al., Journal of Hypertension 1996, vol. 14, No. 3, 355-362. Hypotensive Action of 5-HT Receptor Agonists in the Vitamin B6-Deficient Hypertensive Rat, Lal et al., Euro pean Journal of Pharmacology, 234(1993) 183-189. Sympathetic Stimulation and Hypertension in the Pyridox ine-Defici...

Dehydroepiandrosterone-fatty acyl esters (DHEA-FAE) belong to a unique family of naturally occurring hydrophobic steroid hormone derivatives that are transported in circulating lipoproteins and may act as a source of dehydroepiendrosterone (DHEA) and other biologically active steroid hormones in cells. Here, we studied the metabolic fate of low-density lipoprotein-associated [(3)H]DHEA-FAE ([(3...

This study investigated whether trait-like differences in brain monoaminergic functioning relate to differential vulnerability for the long-term neurochemical depletion effects of MDMA. Genetically selected aggressive (SAL) and non-aggressive (LAL) house-mice differing in baseline serotonergic and dopaminergic neurotransmission were administered MDMA. An acute binge-like MDMA injection protocol...

INTRODUCTION Lysosomal acid lipase deficiency (LAL-D) causes progressive cholesteryl ester and triglyceride accumulation in the lysosomes of hepatocytes and monocyte-macrophage system cells, resulting in a systemic disease with various manifestations that may go unnoticed. It is indispensable to recognize the deficiency, which can present in patients at any age, so that specific treatment can b...

Understanding shielding cross-effects is a prerequisite for maximal power-specific nanosecond laser ablation in liquids (LAL). However, discrimination between cavitation bubble (CB), nanoparticle (NP), and shielding, e.g., by the plasma or transient vapor layer, challenging. Therefore, CB imaging shadowgraphy performed to better understand beam-NP interaction during LAL. By comparing fluence-de...

Natural language processing (NLP) programs are confronted with various di culties in processing HTML and XML documents, and have the potential to produce better results if linguistic information is annotated in the source texts. We have therefore developed the Linguistic Annotation Language (or LAL), which is an XML-compliant tag set for assisting natural language processing programs, and NLP t...

PURPOSE To determine the feasibility of creating customized multifocal and aspheric patterns onto a light-adjustable lens (LAL) using a digital light delivery (DLD) system. METHODS Silicone LALs were placed in a wet cell and irradiated in vitro using the DLD. Spatial intensity patterns were designed and generated to (1) create a multifocal optic with customized power and diameter and (2) simu...

Abstract. This work is a consequence of studying the (un)relatedness of the principles that allow to implicitly characterize the polynomial time functions (PTIME) under two perspectives. One perspective is predicative recursion, where we take Safe Recursion on Notation as representative. The other perspective is structural proof theory, whose representative can be Light Affine Logic (LAL). A wa...

References: Quanquan Gu and Jiawei Han. 2012. Towards active learning on graphs: An error bound minimization approach. In Proceedings of ICDM 2012. Dengyong Zhou, Oliver Bousquet, Thomas Navin Lal, Jason Weston, and Bernhard Scholkopf. 2004. Learning with local and global consistency. In Proceedings NIPS, pages 321– 328. Batia Laufer and Paul Nation. 1999. A vocabularysize test of controlled pr...

In spite of its clinical and nutritional importance, l-alanyl-l-glutamine (Ala-Gln) has not been widely used due to the absence of an efficient manufacturing method. Here, we present a novel method for the fermentative production of Ala-Gln using an Escherichia coli strain expressing l-amino acid alpha-ligase (Lal), which catalyzes the formation of dipeptides by combining two amino acids in an ...