Focal adhesions (FAs) control cell shape and motility, which are important processes that underlie a wide range of physiological functions. FA dynamics is regulated by cytoskeleton, motor proteins and small GTPases. Kinectin is an integral endoplasmic reticulum (ER) membrane protein that extends the ER along microtubules. Here, we investigated the influence of the ER on FA dynamics within the c...

DSAP: Disseminated superficial actinic porokeratosis DSP: Disseminated superficial porokeratosis INTRODUCTION The porokeratoses are a group of disorders of abnormal epidermal keratinization resulting in the characteristic histologic feature of the cornoid lamella. Several clinical variants of porokeratosis exist, which are unified by this common histologic feature but differ in morphology, dist...

PURPOSE To compare the use of swollen tissue versus tissue deswollen by addition of dextran to the medium in the dissection of organ-cultured Descemet membrane (DM) with regard to preparation-related characteristics and ultrastructural findings to optimize transplantation in Descemet membrane endothelial keratoplasty (DMEK). METHODS DMs of 20 corneoscleral rims were separated using organ-cult...

Successive changes in the vascular pattern during the osseous healing of extraction wounds were investigated by studying microvascular casts under a scanning electron microscope. The casts were prepared utilizing the plastic injection method, after the extraction of the upper four incisors of the Japanese monkey (Macaca fuscata). Five days after extraction, vascular buds have sprouted from a pr...

The role of short chain branches (SCBs) (C4H9) on the melt and crystalline properties monodisperse polyethylene systems (C400H802) is investigated, using molecular dynamics simulations a coarse-grained united-monomer model that represents chemical monomer as one particle. A method introduced, whereby SCBs are grown out linear backbone to minimize computational expense. Here, this concept proven...

BACKGROUND Intraocular pressure (IOP) measurements using Goldmann applanation tonometry (GAT) are influenced by central corneal thickness (CCT) whereas dynamic contour tonometry (DCT) allows for IOP measurements independent of CCT. After Descemet's stripping automated endothelial keratoplasty (DSAEK) the CCT is, compared to healthy eyes, increased. The objective of this prospective study was to...

The strength and ductility of nanolayered materials are determined by a delicate balance between dislocation and interface motion under applied mechanical loading. We present here studies of dislocation and interface motion in single crystal and nanotwinned copper, utilizing molecular dynamics simulations. Motion of twin boundary interfaces themselves is dictated by the stress state at the inte...