INTRODUCTION The development of treatment guidelines emerged as an important element so as to standardize treatment and to provide clinicians with algorithms, which would be able to carry research findings to the everyday clinical practice. MATERIAL AND METHOD The MEDLINE was searched with the combination of each one of the key words 'mania', 'manic', 'bipolar', 'manic-depression', 'manic-dep...

OBJECTIVE To analyze seizure control and treatment in pregnant women with epilepsy. METHODS Seizure control and treatment were recorded prospectively in 1,956 pregnancies of 1,882 women with epilepsy participating in EURAP, an international antiepileptic drugs (AEDs) and pregnancy registry. RESULTS Of all cases, 58.3% were seizure-free throughout pregnancy. Occurrence of any seizures was as...

OBJECTIVE The aim of the current study is to determine whether pharmacotherapy normalizes cognitive circuitry function supporting voluntary behavioral inhibition in adolescent bipolar disorder. METHOD Healthy controls and unmedicated patients with DSM-IV adolescent bipolar disorder in manic, mixed, or hypomanic episodes were matched on demographics and IQ (n = 13 per group; mean age = 14.4 ± ...

PURPOSE The aim of this study was to compare the serum levels of one-carbon metabolism (OCM) nutrients (e.g., folate, homocysteine and vitamin B12) and peripheral blood DNA methylation in epileptic patients under treatment with antiepileptic drugs (AEDs) and in healthy controls. METHODS In this cross-sectional study, 60 patients with epilepsy who were receiving valproate (VPA) (n = 30) or lam...

Lamotrigine (LTG) is increasingly being prescribed in pregnancy for women with epilepsy in place of valproate (VPA), because of the teratogenic risks associated with the latter. It is therefore important to know the teratogenic hazard associated with LTG, relative to VPA and to other commonly used antiepileptic drugs (AEDs). Data from the Australian Register of Antiepileptic Drugs in Pregnancy ...

how to cite this article: asadi-pooya aa, emami m. effects of antiepileptic drugs on electroencephalographic findings inpatients with idiopathic generalized epilepsy. iranian journal of child neurology 2011;5(4):33-36. objective several antiepileptic drugs (aeds) such as phenobarbital (pb), carbamazepine (cbz), and valproate (vpa) may suppress interictal epileptiform activity. we investigated t...