BACKGROUND AND OBJECTIVES Lanthanum carbonate (FOSRENOL, Shire Pharmaceuticals) is an effective noncalcium, nonresin phosphate binder for the control of hyperphosphatemia in chronic kidney disease (CKD) stage 5 patients undergoing dialysis. DESIGN, SETTING, PARTICIPANTS AND MEASUREMENTS A Phase 2, randomized, double-blind, placebo-controlled trial evaluating the efficacy and safety of lanthan...

In this paper, we have proposed a simple method to covalently conjugate biotin to magnetic nanoparticles, which can be targeted to the tumour sites by using pretargeting approach with avidin or streptavidin. Magnetic nanoparticles of manganese ferrite were synthesized by alkaline coprecipitation of ferric chloride hexahydrate, ferrous sulphate heptahydrate and manganese sulphate monohydrate usi...

The ability of lanthanum chloride (LaCl3) to retard the progression of established atherosclerosis was investigated in cholesterol-fed rabbits. Rabbits were initially maintained on a high-fat plus cholesterol-supplemented diet for 10 weeks to induce lesions and were then changed to a low-fat diet or a low-fat diet supplemented with LaCl3 for an additional 24 weeks to permit their serum choleste...

Hyperphosphatemia has been shown to be involved not only in the onset and progression of secondary hyperparathyroidism but also in vascular calcification. In addition, it influences the clinical course of patients with chronic kidney disease. Phosphate (Pi) binder is required in the management of hyperparaphosphatemia, because dietary Pi restriction and Pi removal by hemodialysis alone are insu...

Studies were conducted to compare the phosphate-binding efficacy of lanthanum carbonate directly with other clinically used phosphate binders and to evaluate any potential adverse pharmacology. To examine the phosphate-binding efficacy, rats with normal renal function and chronic renal failure received lanthanum carbonate, aluminum hydroxide, calcium carbonate, or sevelamer hydrochloride in sev...

The tiltle complex, [La(2)(C(7)H(7)NO(2))(4)Cl(2)(H(2)O)(6)]Cl(4)·2H(2)O, is a centrosymmetric dimer formed by edge-sharing LaO(5)(H(2)O)(3)Cl polyhedra linked together by a carboxyl-ate ligand. The two La(III) metal ions are linked by two bidentate bridging carboxyl-ate groups with a κ(2)O:O' coordination mode and two bidentate chelating bridging carboxyl-ate groups with a κ(3)O:O,O' coordinat...

BACKGROUND Phosphate binders, such as lanthanum carbonate, control elevated serum-phosphate levels in patients with end-stage renal disease (ESRD). Lanthanum carbonate is available in oral powder and tablet form. The aim of this survey was to investigate satisfaction with, preference for, and adherence to lanthanum carbonate oral powder in patients with ESRD. SCOPE Patients from France and Sp...

Correction of metabolic acidosis after conversion from sevelamer hydrochloride to lanthanum carbonate Sir, We recently introduced lanthanum carbonate as an alternative phosphate binder to sevelamer hydrochloride in patients with elevated serum calcium. Lanthanum carbonate has a higher affinity for phosphate than sevelamer HCl, so fewer lanthanum carbonate tablets are required to achieve the sam...

Fragrant rice (Oryza sativa L.) is a high-valued type and possesses unique aroma with 2-acetyl-1-pyrroline (2-AP) as the critical component. However, cultivation measures in fragrant production are far from perfect. In this study, new organic-inorganic compound fertilizer was made organic matter, urea, superphosphate, potassium chloride, zinc sulfate, lanthanum chloride. A four-year field exper...