Laser Doppler flowmetry is a well-established tool for imaging flows. It has been used as a clinical tool for measuring microcirculation in superficial tissue for applications including studies of allergic reactions, burn depth assessment, skin cancer diagnosis, assessment of skin diseases and investigating the effects of transdermal drug delivery. Imaging is often performed by scanning a singl...

OBJECTIVE To examine the effects of hypertonic/hyperoncotic treatment on physiologic variables and regional cerebral blood flow and to test its neuroprotective efficiency in a model of permanent venous ischemia. DESIGN Randomized prospective study. SETTING University research institute. SUBJECTS Adult male Wistar rats, weighing 359 +/- 54 g (n = 38). INTERVENTIONS Rats were subjected to...

During the course of a study of skin blood flow under applied external pressure, it became apparent that decreasing blood flow by loading the skin surface reveals problems that are fundamental to the method of laser Doppler flowmetry. These problems have to do with the fact that the laser Doppler is extremely sensitive to red cell motion of any kind, whether associated with the ordered red cell...

Aim—The eVect of breathing 100% oxygen on retinal and optic nerve head capillary blood flow in smokers and non-smokers was investigated using scanning laser Doppler flowmetry (SLDF) as a new noninvasive method to visualise and quantify ocular blood flow. Method—10 eyes of 10 young healthy nonsmoking volunteers (mean age 26 (SD 3) years) and nine eyes of nine young healthy smoking volunteers (me...

BACKGROUND Cutaneous laser Doppler flowmetry enables monitoring of changes in skin perfusion by quantifying the phase shift of laser light induced by moving red blood cells under a fiberoptic probe. It thus can identify the presence of and response to a vasoconstrictive stimulus. However, aspects of the technique must be defined before it can be used with maximum effectiveness. We evaluated the...

Systemic sclerosis is a connective tissue disease characterized by alterations in microvascular structure and function. In these patients, numerous studies have demonstrated a relationship between capillary morphology and peripheral blood perfusion. Nailfold videocapillaroscopy reveals the peripheral microvascular morphology and thus allows classification and scoring of capillary abnormalities ...

Reduced cochlear blood flow (CoBF) is a main contributor to hearing loss. Studying CoBF has remained a challenge due to the lack of available tools. Doppler optical microangiography (DOMAG), a method to quantify single-vessel absolute blood flow, and laser Doppler flowmetry (LDF), a method for measuring the relative blood flow within a large volume of tissue, were used for determining the chang...