Purpose. To investigate fundamental mechanisms of regimes of laser induced damage to the retina and the morphological changes associated with the damage response. Methods. Varying grades of photothermal, photochemical, and photomechanical retinal laser damage were produced in eyes of eight cynomolgus monkeys. An adaptive optics confocal scanning laser ophthalmoscope and spectral domain optical ...

OBJECTIVE To determine the effect of the axial length of the eye on laser spot size and irradiance. DESIGN Experimental study using a calibrated Gullstrand-type model eye. METHODS The model eye, which was fitted with a scale of half circles in the center of the artificial fundus, was first examined using 2 different fundus imaging systems, then with a setup of a slitlamp, 2 indirect condens...

OBJECTIVE Transmyocardial laser revascularization (TMLR) has been used to provide enhanced myocardial perfusion in patients not suitable for coronary revascularization or angioplasty. This study investigates the acute changes in myocardial perfusion after TMLR with a Holmium:Yttrium-Aluminium-Garnet (YAG) laser with a thermal imaging camera in a model of acute ischaemia, and confirms its midter...

OBJECTIVE To evaluate a newly developed laser-based imaging technique for the study of soft tissue changes and acute inflammatory processes of the proximal interphalangeal (PIP) joints in patients with rheumatoid arthritis (RA). METHODS A novel imaging device was developed which allows the transillumination of PIP joints using laser light in the near-infrared wavelength range. In a first clin...

A combination of planar laser imaging and theoretical modeling has been used to examine matrix-assisted pulsed-laser evaporation direct write MAPLE-DW in the bubble regime. MAPLE-DW is a method for patterning substrates via laser-initiated forward transfer of an organic fluid containing metallic particles and coated on a transparent support. For our conditions, best deposition of a silver-based...

The study of pulsed laser- and microwave-induced plasma interactions with atmospheric and higher pressure combusting gases requires rapid diagnostic methods that are capable of determining the mechanisms by which these interactions are taking place. New rapid diagnostics are presented here extending the capabilities of Rayleigh and Thomson scattering and resonance-enhanced multi-photon ionizati...

In this chapter an introduction will be given to the research areas of high-speed laser Doppler perfusion imaging and laser speckle contrast techniques. Furthermore, the aim of the performed research will be introduced, and finally an overview of the topics in this thesis will be given. 1.1 General Introduction Noninvasive imaging of blood flow in tissue is of major importance for certain appli...

Laser speckle imaging (LSI) based on the speckle contrast analysis is a simple and robust technique for imaging of heterogeneous dynamics. LSI finds frequent application for dynamical mapping of cerebral blood flow, as it features high spatial and temporal resolution. However, the quantitative interpretation of the acquired data is not straightforward for the common case of a speckle field form...

PURPOSE The incidental detection of small renal masses is increasing. However, not all require aggressive treatments as up to 20% are benign and the majority of malignant tumors harbor indolent features. Improved preoperative diagnostics are needed to differentiate tumors requiring aggressive treatment from those more suitable for surveillance. We evaluated and compared confocal laser endomicro...