Marked variations in food intake have been described in various species following injury to certain parts of the hypothalamus, including an increased food intake or hyperphagia caused by lesions in the medial hypothalamus, especially lesions in or ventrolateral to the ventromedial nucleus; this hyperphagia leads to obesity."1418' 20 24 A decrease or complete inhibition of food intake has also b...

Nicotinic acetylcholine receptors (nAChRs) play an important role in regulating appetite and have been shown to do so by influencing neural activity in the hypothalamus. To shed light on the hypothalamic circuits governing acetylcholine's (ACh) regulation of appetite this study investigated the influence of hypothalamic nAChRs expressing the α4 subunit. We found that antagonizing the α4β2 nAChR...

Histidine decarboxylase (HDC) catalyzes the biosynthesis of histamine from L-histidine and is expressed throughout the mammalian nervous system by histaminergic neurons. Histaminergic neurons arise in the posterior mesencephalon during the early embryonic period and gradually develop into two histaminergic substreams around the lateral area of the posterior hypothalamus and the more anterior pe...

WOLF, GEORGE. Hypothalamic regulation of sodium intake: relations to preoptic and tegmental function. Am. J. Physiol. 213(G): 1433-1438. 1967.-Rats with lesions of the septum, lateral preoptic area, or ventral tegmental area of Tsai showed no impairment of sodium appetite after adrenalectomy, acute sodium depletion, or deoxycorticosterone treatment. Rats with lesions of the lateral hypothalamus...

The effects of intrahypothalamic carbachol microinjections were investigated in unprovoked cats. The carbachol evoked mydriasis, attention, vocalization, and piloerection, i.e. features of a typical defense were usually concomitant in evoked response, while the clear-cut aggressive or escape patterns appeared only once. No basic differences were observed in the set of manifestations induced by ...