Abstract Background Transcriptional coactivator with PDZ-binding motif (TAZ) has been reported to be involved in tumor progression, angiogenesis, epithelial-mesenchymal transition (EMT), glycometabolic modulation and reactive oxygen species (ROS) buildup. Herein, the underlying molecular mechanisms of TAZ-induced biological effects bladder cancer were discovered. Methods qRT-PCR, western blotti...

Aberrant STING and Interferon (IFN) signaling are hallmarks of SLE, a female-biased disease, where amplified type I IFN responses by keratinocytes (KCs) lead to increased Stimulated Genes (ISGs) expression. Here we show that HERC6, which encodes for an E3 ubiquitin ligase, with unknown role in the skin, is induced basal layer human SLE epidermis coinciding marked decrease number sex-biased gene...