Legg-Perthes disease (osteochondritis deformans) is an aseptic necrosis of the capital femoral epiphysis. The clinical and radiographic features of Legg-Perthes disease have been well documented (Goff, Shutkin, and Hersey, 1954; Kemp and Boldero, 1966) but apart from Molloy and MacMahon's Massachusetts study (1966) few epidemiologic investigations have been reported. A genetic component to the ...

Heritable thrombophilic disorders have been proposed as one of the causes for Legg-Calvé-Perthes disease. A total of 62 patients diagnosed with this disease between 1988 and 1997 and 50 controls were screened for thrombophilia. The incidence and relationship of thrombophilia to the severity of the disease were evaluated. One patient and none of the controls had protein S deficiency. One of the ...

Classifications of Legg-Calvé-Perthes disease (LCPD) may be divided into three categories: those defining the stage of the disease, those attempting to prognosticate outcome, and those defining outcome. Although Arthur Legg MD [13], Jacques Calvé [2], and Georg Perthes MD [17] share credit for their descriptions of the disease published between 1909 and 1910, according to Wenger and Pandya, Hen...