A scleral contact lens lies on the sclera, not cornea, which differs from a rigid gas permeable (RGP) lens, and has shown successful clinical outcomes in patients unable to tolerate glasses or RGP lenses because of severely deformed cornea. In addition, forms tear film between cornea that stabilizes ocular surface could be useful therapeutic option. The mini-scleral is option for visual improve...

Cataract is a total or partial clouding of the lens of the eye. It can be congenital or acquired. Cataract associated with the aging process (senile) is the most common type. Common symptoms include visual impairment which varies based on the type and the density of lens opacity. Cataracts etiology is varied and treatment is based on surgery. In patients with morgagnian cataract cortex liquefie...

Tamoxifen is an antiestrogen frequently used in the treatment of breast cancer and is currently being assessed as a prophylactic for those at high risk of developing tumors. We have found that tamoxifen and its derivatives are highaffinity blockers of specific chloride channels. This blockade appears to be independent of the interaction of tamoxifen with the estrogen receptor and therefore refl...

The biochemical evidence regarding a recessively transmitted cataractous trait in mice suggests that an apparent deficiency of Na-K ATPase may be involved in the initiation of this type of cataract. The enzyme defect leads to inefficiency of the cation pump mechanism. This abnormality was demonstrable in 13-day-old mice. At this stage the lens teas clear and the electrolyte levels ivere normal....

Naphthalene cataract is probably due to peroxide production through naphthoquinone (NQ) redox cycling and/or glutathione conjugation. Both mechanisms yield losses of essential SH-groups in cristallins and are thus probably involved in protein modification finally visible as lens opacity. 1,2-Naphthoquinone produces H2O2 in the presence of either ascorbate, glutathione, NADH or--to a lesser exte...

Short-wavelength-sensitive (SWS) resolution acuity has been reported to be limited by the density of the responding ganglion cells for people without appreciable age-related lenticular change. This study measured the robustness of SWS-cone acuity and contrast sensitivity (CS) to simulated lens yellowing and opacification. Resolution acuity at 8 deg eccentricity proved robust to significant amou...

THE most bizarre pattern of lesions may accompany ocular injury. When the violence is severe, damage may amount to complete disruption of the globe. When the violence is moderate, the integrity of the globe may be preserved though the structures within it may be irreparably damaged. Severe intra-ocular haemorrhage or a total lental opacity may cloud the clinical picture. In the latter case a de...

Normal development of the visual system in infants relies on clear images being projected onto the retina, which can be disrupted by lens opacity caused by congenital cataract. This disruption, if uncorrected in early life, results in amblyopia (permanently decreased vision even after removal of the cataract). Doctors are able to prevent amblyopia by removing the cataract during the first sever...

OBJECTIVES To examine the prevalence of radiation-associated lens opacities among interventional cardiologists and nurses and correlate with occupational radiation exposure. BACKGROUND Interventional cardiology personnel are exposed to relatively high levels of X-rays and based on recent findings of radiation-associated lens opacities in other cohorts, they may be at risk for cataract without...