treatment with carbenoxolone sodium resulted in thc increase of free and bound sialic acids to those values found in normal subjects, but no increase above control values was observed. The work now reported shows that treatment of normal adult rats with carbenoxolone results in significant increases in a number of components of the gastric mucus and mucosa. This may be related to the mechanism ...

A series of Pictet-Spengler condensation derivatives (tetrahydro-β-carbolines) was designed, synthesized and evaluated for lethality against a panel of seven cancer cell lines. Seven compounds (2a, 13, 20, 21, 27, 29 and 34) showed lethality in at least five cell lines. Among these, compound 27 showed a unique selectivity towards oncogenic-RAS expressing BJ-TERT/LT/ST/RAS(V12) tumor cells, comp...

The concept of lethality is essential to the assessment of suicide risk; yet operational definitions of lethality for purposes of its measurement have been loose and varied. A number of scaling measures have been published in the literature, with no relative consensus on the best of these. In addition, only a few of these scales have published data on their psychometric properties. Of these, we...