background: previous researches about the effect of smoking on semen quality are contradictory, and the mechanism behind the harmful effect of smoking on semen quality still remains unclear until today. objective: the objectives of this study are evaluation of the relationship between smoking and fertility, investigation of the effects of cigarette smoking on sperm parameters and detection of p...

Introduction: Carbon monoxide (CO) poisoning is one of the most common poisonings worldwide. Many studies have investigated relationship between predictive parameters and CO severity. We aimed to investigate blood parameter values with poor outcome in poisoning, measured blood. Methods: This a retrospective study. Patients who had levels ≥ %10 their gas were included divided into 2 groups as th...

PURPOSE Paclitaxel encapsulated in cationic liposomes (EndoTAG-1) is a vascular targeting formulation for the treatment of solid tumors. It triggers intratumoral microthrombosis, causing significant inhibition of tumor perfusion and tumor growth associated with endothelial cell apoptosis. Here, we quantified the effects of repeated EndoTAG-1 therapy on tumor microvascular leakiness with respect...

Background: Transfusion therapy is an effective treatment method but comes with inherent risks such as transfusion reactions, infection transmission, alloimmunization, and platelet refractoriness. Leukocyte reduction, achieved through apheresis or pre- post-storage filtration, aims to mitigate these potentially reduce the need for antibiotics hospital stays.
 Methods: To conduct this syste...

this study was aimed to evaluate the efficacy of dipstick tests (leukocyte esterase and nitrite) in diagnosis of spontaneous bacterial peritonitis (sbp) in cirrhotic patients. forty six children with ascites hospitalized between 2009 and 2010 in children medical center were enrolled in this study. reagent strip assays for leukocyte esterase and nitrite were performed on ascetic fluid and the re...

I N 1985, a review article appeared in this journal that examined the interactions of leukocytes with vascular endothelium during an immune or inflammatory response.’ The basic physiology of leukocyte emigration as well as disease states in which alterations of leukocyte-endothelial interactions may contribute to pathology were discussed. Since then there has been an explosion of interest in th...

Inhaled corticosteroids have been proposed to decrease pulmonary inflammation in cystic fibrosis (CF). In this study the effects of therapy with inhaled fluticasone on clinical and sputum outcomes (leukocyte count, activity of myeloperoxidase, superoxide anion release) in adult CF patients were investigated in an open label design. Twenty-six stable patients (median+/-SD forced expiratory volum...

Evidence shows that leukocyte recruitment into inflamed liver sinusoids does not require selectins, with one notable exception: ischemia-reperfusion (I/R). We used intravital microscopy to directly visualize the liver microcirculation during I/R and localized endotoxemia (liver superfused with lipopolysaccharide). General anti-selectin therapy (fucoidan) or anti-adhesion therapy with an antithr...

Background: Mutation in NPM1 gene has been reported to be the most common genetic mutation in de novo acute myeloid leukemia (AML). AML with NPM1 gene mutation usually presents with higher initial leukocyte and blast cell counts and negative CD34 expression. We aimed to investigate the difference of initial leukocyte counts, bone marrow blast cell counts and expression of CD34 among patients wi...

background cannabis is one of the most widely used illicit drugs in india and worldwide. it is considered to have a minimal effect on physical health. objectives the aim of this study was to compare the laboratory profiles of treatment-seeking patients who were cannabis dependent, and drug users who concurrently use other substances, with non-users. materials and methods medical records of pati...