نتایج جستجو برای: leukoencephalopathy

تعداد نتایج: 4847  

2017
Josefine Blume Robert Weissert

Early motor symptoms of neurodegenerative diseases often appear in combination with psychiatric symptoms, such as depression or personality changes, and are in danger of being misdiagnosed as psychogenic in young patients. We present the case of a 32-year-old woman who presented with rapid-onset depression, followed by a hypokinetic movement disorder and cognitive decline during pregnancy. Gene...

2017
Manon Dekeyser Marie-Ghislaine de Goër de Herve Houria Hendel-Chavez Céline Labeyrie David Adams Ghaïdaa Adebs Nasser Jacques Gasnault Antoine Durrbach Yassine Taoufik

Progressive multifocal leukoencephalopathy (PML) is a deadly demyelinating disease due to central nervous system replication of the human polyomavirus JC virus (JCV) in immunosuppressed patients. The only effective therapeutic approach is to restore anti-JCV T-cell responses. In this study, we describe a case of rapidly fatal PML with JCV T-cell anergy in a renal transplant patient treated with...

Journal: :iranian journal of child neurology 0
parvaneh karimzadeh 1. pediatric neurology research center, shahid behesti university of medical sciences, tehran, iran 2. department of pediatric neurology, pediatric neurology center of excellence, faculty of medicine, mofid children hospital, shahid behesti university of medical sciences, tehran, iran

how to cite this article: karimzadeh p. pelizaeus-merzbacher- disease (pmd) and pelizaeus-merzbacher-like disease (pmld). iran j child neurol autumn 2014;8:4 (suppl.1):9-10.   pls see pdf.

Journal: :Alzheimers & Dementia 2023

Background Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is a rare autosomal dominant disorder caused by mutations in the colony-stimulating factor 1 receptor (CSF1R) gene. As of 2022, more than 100 different CSF1R were reported patients CSF1R-related leukoencephalopathy. Method In this case report, we described ALSP previously healthy 46-year-old woman. The pa...

2013
Katrin Hirschvogel Kaspar Matiasek Katharina Flatz Michaela Drögemüller Cord Drögemüller Bärbel Reiner Andrea Fischer

BACKGROUND Leukoencephalomyelopathy is an inherited neurodegenerative disorder that affects the white matter of the spinal cord and brain and is known to occur in the Rottweiler breed. Due to the lack of a genetic test for this disorder, post mortem neuropathological examinations are required to confirm the diagnosis. Leukoencephalopathy with brain stem and spinal cord involvement and elevated ...

2015
Reza Vosoughi Brian J. Schmidt

BACKGROUND Cocaine abuse is associated with several mechanisms of brain injury including ischemic, hemorrhagic and metabolic. Recently two case reports of leukoencephalopathy in cocaine users implicated a commonly used cocaine adulterant, levamisole. One well-documented adverse effect of levamisole, when used alone as antihelminthic or immunomodulatory drug, is multifocal inflammatory leukoence...

Journal: :Archives of neurology 2009
Maria del Pilar Martin Petra D Cravens Ryan Winger Bernd C Kieseier Sabine Cepok Todd N Eagar Scott S Zamvil Martin S Weber Elliot M Frohman Betty K Kleinschmidt-Demasters Thomas J Montine Bernhard Hemmer Christina M Marra Olaf Stüve

BACKGROUND Rituximab is a recombinant chimeric monoclonal antibody against CD20, a molecule expressed on cells of the B-cell lineage. A phase 2 clinical trial recently provided strong evidence of the beneficial effects of rituximab in patients with relapsing-remitting multiple sclerosis. We and other investigators previously demonstrated that rituximab therapy depletes B lymphocytes from periph...

2014
Reginald C. Adiele

Progressive multifocal leukoencephalopathy (PML) is a rare, myelin-damaging disease of the central nervous system (CNS) in a setting of immunosuppression that is superimposed by concurrent autoimmune diseases such as multiple sclerosis and AIDS or simultaneous administration of immune modulatory monoclonal antibody drugs such as natalizumab. The causative agent is a Polyomavirus known as John C...

Journal: :Onkologie 2007
Andrew D Norden Tracy T Batchelor

Journal: :Current treatment options in neurology 2008
Allen J Aksamit

Treatment of progressive multifocal leukoencephalopathy (PML) in a patient with exogenous immunosuppression starts with discontinuation of immunosuppressive medication. The restored host immunity will clear JC virus, the cause of PML, from the brain via cell-mediated immune mechanisms. Patients with solid-organ transplants will lose the transplanted organ, however, and patients who have autoimm...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید