Terrestrial plants have proven to be a prolific producer of clinically effective antimalarial drugs, but the antimalarial potential of seaweeds has been little explored. The main aim of this study was to assess the in vitro chemotherapeutical and prophylactic potential of the extracts of twenty-three seaweeds collected from the south coast of England against blood stage (BS) and liver stage (LS...

Cytotoxic T lymphocytes release granzymes (Gzm) A and B to induce apoptosis or programmed cell death of virally infected or tumor cells. In this issue of Cell, Fan et al. identify the tumor metastasis suppressor NM23-H1 as a GzmA-activated, apoptosis-inducing DNase and the oncoprotein SET as its inhibitor. Work from the Lieberman and Wang groups indicates a surprising role for a group of acidic...

Explaining the long-term coexistence of many species in a complex ecosystem has been an important topic in both ALife and ecology for several decades. Neutral and niche theories have been developed in parallel to explain ecological patterns of coexistence. Among the niche theories, trade-offs between species seem to play important roles in the mechanism of most models proposed so far. One of th...

in the present study, the toxic effects on the embryos and larvae of the turbot were used as a model to investigate the diazinon, which contaminates aquatic ecosystems. the number of dead embryos significantly increased in response to diazinon concentrations 0.2, 0.4, 0.8, 1.6, 3.2, and 7.4 mg/l. the 48h lc50 value of diazinon for turbot embryos was estimated at 1.85 mg/l. dose–response decrea...

in the present study, the toxic effects on the embryos and larvae of the turbot were used as a model to investigate the diazinon, which contaminates aquatic ecosystems. the number of dead embryos significantly increased in response to diazinon concentrations 0.2, 0.4, 0.8, 1.6, 3.2, and 7.4 mg/l. the 48h lc50 value of diazinon for turbot embryos was estimated at 1.85 mg/l. dose–response decreas...

This paper presents a two-stage integrated approach to assess the reliability of components for reuse in the second life cycle. Statistical data analysis, the first stage of the proposed method, determines the mean life of components by analysing the time-to-failure data for an electric motor and gearbox of a washing machine. A well-known reliability assessment method, Weibull analysis has been...

BACKGROUND Duodenal cancer is the leading cause of cancer death in familial adenomatous polyposis after colorectal cancer. The lifetime risk for developing duodenal cancer is 4% to 10%. Current treatment guidelines recommend endoscopic surveillance with a prophylactic pancreaticoduodenectomy in advanced duodenal polyposis, defined using the Spigelman staging system. Because no clinical trials h...

Cancer is a major health issue worldwide. Likewise in Malaysia as reported by Lim (2005), “this disease has become increasingly important as a public health concern with the development and progress that has been achieved in this country” (p. 37). According to the Malaysian National Cancer Registry report 2002, one in four Malaysians will get cancer in their life time (Lim et al., 2003). This m...

Recognizing the significance of the life stage of fish for nano-eco-toxicological studies, the acute toxicity of colloidal silver nanoparticles (AgNPs) was tested in three different life stages of rainbow trout. Fishes were exposed to colloidal AgNPs at nominal concentrations of 100, 32, 10, 3.2, 1, 0.32, 0.1, and 0.032 mg/L. The estimated 96 hr LC50 values were 0.25, 0.71, and 2.16 mg/L for th...