BACKGROUND: Most analyses of spatial clustering of disease have been based on either residence at the time of diagnosis or current residence. An underlying assumption in these analyses is that residence can be used as a proxy for environmental exposure. However, exposures earlier in life and not just those in the most recent period may be of significance. In breast cancer, there is accumulating...

Considerable epidemiological data have accumulated in support of a lower risk of breast cancer among physically active women. Few studies, however, have examined the relation with lifetime physical activity from all sources, and moderate activity in particular. We conducted a population-based case-control study of breast cancer in Latinas, African Americans, and whites aged 35-79 years to asses...

BACKGROUND Diesel engine exhaust (DEE) has recently been classified as a known human carcinogen. OBJECTIVE We derived a meta-exposure-response curve (ERC) for DEE and lung cancer mortality and estimated lifetime excess risks (ELRs) of lung cancer mortality based on assumed occupational and environmental exposure scenarios. METHODS We conducted a meta-regression of lung cancer mortality and ...

Introduction: The dose in computed tomography (CT) often approach or exceed the optimum levels, thereby increasing the probability of cancer induction. With wide application of this diagnostic test, it is expedient to determine the effective dose (ED) for each patient to estimate their cancer risk. This study was conducted to investigate the patient-specific dose (PSD) and cancer risk in CT exa...

Genetic testing of seven single-nucleotide polymorphisms (7SNP) can improve estimates of risk of breast cancer relative to the Gail risk test alone, for the purpose of recommending MRI screening for women at high risk. A simulation of breast cancer and health care processes was used to conduct a virtual trial comparing the use of the 7SNP test with the Gail risk test to categorize patients by r...

The incidence and mortality from coronary heart disease (CHD) in Japan are reported to be among the lowest of all industrialized countries,1,2 but, in the backdrop of major dietary changes and worsening cardiovascular risk factors,2 recent reports have shown an increasing trend of acute myocardial infarction (AMI) in the Japanese population.3,4 With the aging of the population and the presence ...