Warfarin and unfractionated heparin have been in clinical use for more than 50 years. Both are effective anticoagulants, but their use is associated with a number of impediments, including the need for intensive coagulation monitoring, wide variation in dose-response relationships, multiple drug interactions (in the case of warfarin), and serious immune-mediated thrombocytopenia (in the case of...

In today’s era of data sharing, immediate communication and world-wide distribution of participants, at a time when teams are asked to be ever more agile, the traditional approach of model repositories no longer meets expectations. Centralized organization has become inconsistent with the way in which the world and its companies function. In today’s world, it is virtually impossible to set up a...

Comparing market estimates for wireless personal communication and considering recent proposals for wideband multimedia services with the existing spectrum allocations for these types of systems show that spectrum resource management remains an important topic in the near and distant future. In this article the authors star t out by presenting a quite general formulation of the radio resource m...

Beavis’ (1998) study on “power, precision, and accuracy” of QTL mapping is a classic. His work (first reported at a symposium in 1994) was the first demonstration of the effects of small sample sizes on the reliability of QTL mapping. This work demonstrated that when sample sizes (n) were small, power to detect true QTL was low, and the bias in the estimated proportion of the genetic variance e...

Adult patients seeking orthodontic treatment are increasingly motivated by esthetic considerations. The majority of these patients reject wearing labial fixed appliances and are looking instead to more esthetic treatment options, including lingual orthodontics and Invisalign appliances. Since Align Technology introduced the Invisalign appliance in 1999 in an extensive public campaign, the appli...

The process of estimation of dose at a target organ from the measurements of environmental concentration of potentially hazardous agents is theoretically examined. The analysis of the estimation process suggests that the design of any study which aims to find the health effects of an agent or to construct a dose-response relationship from environmental measurements must be fully scrutinized to ...

Five experiments were conducted with 282 f'mishing pigs to evaluate the use of condensed fermented corn solubles with germ meal and bran as an amino acid source for swine. This wet milling byproduct referred to as dried steep liquor concentrate (DSLC) is becoming a major byproduct of the industry as methods of corn processing change. DSLC serving as the only amino acid supplement for corn suppo...

A discussion of minimum possible antenna quality factor ( ) is first presented in the paper. Based on the spherical wave function theory, the maximum possible ratios of gain to for both directional antenna and omnidirectional antenna are examined and new upper limits for both cases have been obtained. Universally applicable numerical results and some related discussions are also included in the...