autosomal dominant polycystic kidney disease (adpkd) is the most common genetic nephropathy, which is characterized by replacement of renal parenchyma with multiple cysts. in iran, the disease prevalence within the chronic hemodialysis patient population is approximately 8-10%. so far, three genetic loci have been identified to be responsible for adpkd. little information is available concernin...

This report investigates the use of Linkage Learning in Genetic Algorithms (GAs) to try and determine why it is worthwhile using this technique to improve the power of GAs. This report first introduces GAs and how they go about converging on optimal solutions with comparison to other search algorithms. Then it discusses what linkage learning is and several of the techniques used to perform link...

Studies involving the use of probabilistic record linkage are becoming increasingly common. However, the methods underpinning probabilistic record linkage are not widely taught or understood, and therefore these studies can appear to be a 'black box' research tool. In this article, we aim to describe the process of probabilistic record linkage through a simple exemplar. We first introduce the c...

Linkage disequilibrium (LD) is bases of genomic selection, genomic marker imputation, marker assisted selection (MAS), quantitative trait loci (QTL) mapping, parentage testing and whole genome association studies. The Particular alleles at closed loci have a tendency to be co-inherited. In linked loci this pattern leads to association between alleles in population which is known as LD. Two metr...

Two breeds of chickens were used to develop reference family and detect QTLs affecting egg quality traits: cocks of a native Polish breed Green-Legged Partidgenous (GlP) and hens of Rhode Island Red (RIR). During the first 100 days of the laying period, the GlP hens lay about 40 eggs weighting on average 50 g, whilst the RIR flock laid 83 eggs with a mean weight of 60 g. QTL analysis of egg qua...

many agriculturally important traits are complex, affected by many genes and the environment. quantitative trait loci (qtl) mapping is a key tool for studying the genetic structure of complex traits in plants. in the present study qtls associated with yield and agronomical traits such as leaf number, leaf length, leaf width, plant height, stem and head diameter were identified by using 70 recom...

BACKGROUND Record linkage techniques are widely used to enable health researchers to gain event based longitudinal information for entire populations. The task of record linkage is increasingly being undertaken by specialised linkage units (SLUs). In addition to the complexity of undertaking probabilistic record linkage, these units face additional technical challenges in providing record linka...

Saham sebagai salah instrumen investasi jangka panjang dalam pelaksanaannya diperlukan perhitungan dan analisis. Tujuan dari penelitian ini adalah untuk menganalisis keputusan saham IDX High Dividend 20 dengan analisis fundamental mikro. Metode yang digunakan diantaranya yaitu Price Earning Ratio (PER) klaster. Nilai intrinsik diperoleh dibandingkan harga di pasar dilanjutkan pengelompokan meng...