Three predisposition genes have been identified for cutaneous malignant melanoma (CMM), but they account for only ∼25% of melanoma clusters/pedigrees. Linkage analyses of melanoma pedigrees from many countries have failed to identify significant linkage evidence for the remaining predisposition genes that must exist. The Utah linkage analysis approach of using singly informative extended high-r...

OBJECTIVES To identify novel candidate regions for late-onset Alzheimer disease (LOAD) and to confirm linkage in previously identified chromosomal regions. DESIGN Family-based linkage analysis. SETTING Probands with familial LOAD identified in clinics in the Dominican Republic, Puerto Rico, and the United States. Patients We conducted a genome scan in 1161 members primarily clinically diagn...

dermatophytes are a group of keratinophilic fungi capable of invading keratinized tissues (skin, hair and nails). they cause dermatophytosis (commonly known as tinea or ring worm) in human and animals. in this report, dna similarities and genomic linkage of 40 dermatophytes strains was obtained from different universities, were studied by random amplified polymorphic dna (rapd–pcr) using 11 ran...