Plants produce the majority of the world's lipids, and most animals, including humans, depend on these lipids as a major source of calories and essential fatty acids. Like other eukaryotes, plants require lipids for membrane biogenesis, as signal molecules, and as a form of stored carbon and energy. In addition, soft tissues and bark each have distinctive protective lipids that help prevent des...

I propose to give a review of the effect of drugs on lipid metabolism which will be extensive rather than intensive. Several excellent reviews are available that discuss the drugs which are most effective for lowering plasma lipid levels in the six main types of human hyperlipoproteinaemia (Lees & Wilson, 1971 ; British Medical Journal, I 972 ; Levy, Fredrickson, Shulman, Bilheimer, Breslow, St...

Dysregulated lipid metabolism is an established hallmark of cancer. Lipids play diverse roles inmaintaining cellular structure, formingmembrane microdomains for functional scaffolding of protein complexes, serving as fat storage depots, and acting as signaling molecules. All of these processes are critical in cancer not only for generating the membrane constituents necessary for proliferating c...

Acyl lipids in Arabidopsis and all other plants have a myriad of diverse functions. These include providing the core diffusion barrier of the membranes that separates cells and subcellular organelles. This function alone involves more than 10 membrane lipid classes, including the phospholipids, galactolipids, and sphingolipids, and within each class the variations in acyl chain composition expa...

The regulation of lipolysis in adipocytes involves coordinated actions of many lipid droplet (LD)-associated proteins such as perilipin, hormone sensitive lipase (HSL), adipose triglyceride lipase (ATGL), and its activator protein, CGI-58. Recently, the author and my colleagues described the cellular origin and physiological significance of micro LDs (mLDs) that emerge in the cytoplasm during a...

The fetus grows at a rate unparalleled by that during any other stage of life. To maintain its rapid growth rate, the fetus requires a significant amount of cholesterol and fatty acids. For structural purposes alone, the fetus requires 1.5 mg of cholesterol per gram of tissue, not including the brain. Cholesterol is also required as a precursor for various steroidogenic hormones that are critic...

Part 1: The metabolism of cancer cells -- Chapter Glucose Metabolism 2: Glutamine 3: Amino Acid 4: Lipid 5: Epigenetics and oncometabolites Heterogeneity Cancer - Specific oncogenetic mutations lead to specific metabolic phenotypes within the same tissue origin Intratumoral heterogeneity cell Differential in vitro vivo Carcinoma associated fibroblasts Characteristics CAF's Reverse Warbug EFF Me...