The vaginal route of administration is an alternative for several treatments for either local or systemic pharmacological effects. However, the permanence of a drug in this route represents a challenge for formulation development that can be overcome by using nanoencapsulation and chitosan gel. Thus, this work aimed to evaluate the performance of chitosan hydrogels containing cationic and anion...

Lipid nanocapsules (LNC) based on a core-shell structure consisting of an oil-filled core with a surrounding polymer layer are known to be promising vehicles for the delivery of hydrophobic drugs in the new therapeutic strategies in anti-cancer treatments. The present work has been designed as basic research about different LNC systems. We have synthesized-and physico-chemically characterized-t...

Zein prolamine nanocapsules encapsulating polyphenolic compounds extracted from Biloxi blueberries were produced by means of the electrospraying technique and characterized. Nanocapsules prepared with different ratios zein:extract 10: 1, 5: 3.3: 2: using glycerol as an adjuvant. The SEM analysis showed homogeneity in morphology nanocapsules, being not completely spherical, a smooth surface, wit...

Doxorubicin (Dox) clinical use is limited by dose-related cardiomyopathy, becoming more prevalent with increasing cumulative doses. Previously, we developed Dox-loaded lipid-core nanocapsules (Dox-LNC) and, in this study, we hypothesized that self-assembling and interfacial reactions could be used to obtain arginylglycylaspartic acid (RGD)-surface-functionalized-Dox-LNC, which could target tumo...

The latest trends in cancer research and nanomedicine focus on using nanocarriers to target stem cells (CSCs). Specifically, lipid liquid nanocapsules are usually developed as for lipophilic drug delivery. Here, we olive oil NCs (O2LNCs) functionalized by covalent coupling of an anti-CD44-fluorescein isothiocyanate antibody (αCD44). First, O2LNCs formed a core surrounded shell containing phosph...

We designed silica nanocapsules able to encapsulate and release cargo molecules upon the application of a mechanical stress. By tuning architecture nanocapsules, force required induce was successfully controlled.