The effect of ethanolic extract of Coriandrum sativum L. seeds (100, 200 mg/kg) was studied on tacrine induced orofacial dyskinesia. Tacrine (2.5 mg/kg, i.p.) treated animals were observed for vacuous chewing movements (VCM), tongue protrusions (TP) and orofacial bursts (OB) for 1 h followed by observations for locomotor changes and cognitive dysfunction. Sub-chronic administration of Coriandru...

Abstract The aim of the current study was to evaluate therapeutic potentials Hydroxyquinoline Sulfanilamide (HSM) for Alzheimer’s disease in a mice model Streptozotocin (STZ)-induced diabetes. antioxidant analysis brain homogenates carried out by catalase (CAT) assay, reduced glutathione (GSH) and lipid peroxidation (LPO) assay. Biochemical blood plasma conducted peroxidase (POD) assay superoxi...

background: glycowithanolides (withaferin a), is one of the main withanolides active principle isolated from plant withania somnifera and is claimed that it possess the aphrodisiac, sedative, rejuvenate and life prolonging properties. objective: in the present investigation, antioxidant activity of active principles of withania somnifera was tested against d-galactose induced oxidative stress i...

In this study, the activity of methanol extract of Prosopis cineraria (MPC) was evaluated in N-nitrosodiethylamine (DEN, 200mg/kg) induced experimental liver tumor in male Wistar rats. It was found that the administration of MPC (200 and 400mg/kg) effectively suppressed liver tumor induced by N-nitrosodiethylamine (DEN) as revealed by decrease in N-nitrosodiethylamine (DEN) induced elevated lev...

Prooxidants are activated oxygen metabolites (AOM), active oxygen forms and free radicals of any etiology that activate free radical oxidation of all boimolecules, in particular lipids. In pathology the amount of prooxidants increases and free radical oxidation activation processes of all boimolecules, in particular lipids of biological membranes, go out of control. The accumulation of LPO prod...

We investigated the protective role of Withania somnifera leaf extract (WSLEt) on isoproterenol- (ISO-) induced myocardial infarction (MI) in rats. Subcutaneous injection of ISO (85 mg/kg body weight (b.w.)) administered to rats for two consecutive days caused a significant increase in cardiac troponin I (cTnI) levels and serum lipid profiles, as well as the activities of some marker enzymes. I...

Cadmium (Cd) is an environmental and industrial pollutant that affects the male reproductive system. Exposure to cadmium metal is known to induce the formation of reactive oxygen species (ROS) like superoxide radical, hydroxyl ion and hydrogen peroxide. Vitamin E is a lipid phase antioxidant & Vitamin C acts as a potent water soluble antioxidant by scavenging reactive oxygen species. The purpos...

Lipid peroxidation (LPO) is a cellular process that commonly takes place under normal physiological conditions. Under excessive oxidative stress, the level of LPO becomes very significant, and a growing body of evidence has shown that excessive LPO may be involved in carcinogenesis. Trans-4-hydroxy-2-nonenal (4-HNE) is a major product of LPO, and its level becomes relatively high in cells under...

Chronic renal failure is a progressive loss of renal function over a period of months or year and Hemodialysis is a suitable treatment which is preferably given to the chronic renal failure ernment RF) . Who are not to undergo renal transplantation therapy. This study was carried out to observe the immediate effect of oxidative stress and inflammation during hemodialysis . In the present study ...

Free radicals are all known to damage cell components. The present study was designed to evaluate the free radical generation in the testis and liver and also to determine the testicular and hepatic antioxidant enzyme activities with and without catechin administration in thyroxine induced male Sprague-Dawley rats. The experimental animals were divided into four groups, six on each division. L-...