Corona Virus Disease (COVID-19) is announced as pandemic by World Health Organization (WHO) since 11th March 2020. Riau Province has many herbal plants e.g. Cheilocostus specious, Euphorbia hirta l, Cassia torra, Bryophyllum pinnatum, Daniella ensifollia, and Ziziphus mauritiana that can cure diseases there not report yet focusing on in-silico method using SARS-CoV-2 protease (PDB ID:6LU7). Thi...

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common hereditary enzyme defect in humans, caused by a mutation X-linked gene encoding G6PD. The G6PD plays an important role to produced reducing agents which maintain reduced glutathione through pentose phosphate pathway. On ingestion of Faba Bean (Vicia faba L.), vicine and convicine are hydrolyzed β -glucosidase divicine isoura...

Background: Cancer is one of the biggest health problems worldwide, with lung cancer as first rank in number new cases and deaths. Non-small cell carcinoma (NSCLC) a type that accounts for about 85% all cases. Previous research identified role epidermal growth factor receptor (EGFR) most suitable target to treat NSCLC. This study aims identify potential compounds derived from mangrove plants ag...

Sir, Dr. S. Haque Nizamie & P.N. Suresh Kumar in their article 'fluoxetine induced extrapyramidal symptoms: Case reports' in Indian Journal of Psychiatry 1998, Vol. 1,No. 1, 87-89 have categorically remarked absence of suicidal ideation in both the cases who had developed pseudoparkinsonism and akathisia while being treated with fluoxetine alone and in combination with heloperidol & lithium. Ak...

Drug Discovery today conceptualizes on the involvement of chemo informatics to overcome the shortcomings of the traditional Drug development process. Drug Discovery with the use of Chemo informatics and Data Mining generates large numbers of related chemical compounds. It speeds up the drug discovery in two ways: It can generate several million structurally related chemical molecules. By increa...

Altered metabolism is an emerging hallmark of cancer, as malignant cells display a mammoth up-regulation of enzymes responsible for steering their bioenergetic and biosynthetic machinery. Thus, the recent anticancer therapeutic strategies focus on the targeting of metabolic enzymes, which has led to the identification of specific metabolic inhibitors. One of such inhibitors is 3-bromopyruvate (...

The aim of this study was to identify compounds that possess anticonvulsant activity by using a pentylenetetrazol (PTZ)-induced seizure model. Theoretical studies of a set of ligands, explored the binding affinities of the ligands for the GABA(A) receptor (GABA(A)R), including some benzodiazepines. The ligands satisfy the Lipinski rules and contain a pharmacophore core that has been previously ...

a year in the United States. About one-third of all cancer deaths are attributable to poor diet, and four of the top ten causes of death in the United States — heart disease, cancer, stroke, and diabetes — are also associated with poor diet. Dietrelated health conditions cost society an estimated $250 billion annually in medical costs and lost productivity (Frazao). In an effort to make nutriti...

Coronavirus disease (COVID-19), which was due to novel coronavirus detected in December 2019 Wuhan, China for the first time and spread rapidly became a global pandemic. This study aimed predict potential of macroalgae compounds as SARS-CoV-2 antiviral by inhibiting ACE2 receptor through silico approach. Twenty-seven were obtained from PubChem (NCBI, USA), while target protein collected Protein...

Objective: This study was aimed to analyze the inhibitory effect of drugs used in nanocarrier as well nanoparticles formulation based drug delivery system selected from PubChem database literature against 3CLpro (3C-like protease) receptor SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) by implementing several silico analysis techniques. Methods: paper detailed a molecular docking-...