نتایج جستجو برای: lipophilicity
تعداد نتایج: 5219 فیلتر نتایج به سال:
Property tuning by fluorination is very effective for a number of purposes, and currently increasingly investigated for aliphatic compounds. An important application is lipophilicity (log P) modulation. However, the determination of log P is cumbersome for non-UV-active compounds. A new variation of the shake-flask log P determination method is presented, enabling the measurement of log P for f...
In this study, a series of twelve ring-substituted salicylanilides and carbamoylphenylcarbamates were prepared and characterized. The compounds were analyzed using RP-HPLC to determine lipophilicity. They were tested for their activity related to the inhibition of photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. Moreover, their site of action in the photos...
This paper deals with the evaluation of lipophilicity expressed by logPow parameter ten barbiturate derivatives generally used as sedative-hypnotics based on Density Functional Theory (DFT) calculations. All geometry optimizations and frequency calculations have been carried out using DFT/B3LYP/ 6-311++G (d,p) basis set in gas phase also water n-octanol phases. Gibbs free energies solvation for...
A series of twenty-five novel salicylanilide N-alkylcarbamates were investigated as potential acetylcholinesterase inhibitors. The compounds were tested for their ability to inhibit acetylcholinesterase (AChE) from electric eel (Electrophorus electricus L.). Experimental lipophilicity was determined, and the structure-activity relationships are discussed. The mode of binding in the active site ...
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