Single-use bioreactors are commonly used for seeding stainless steel bioreactors or for producing material. The profitability of these equipments has been well demonstrated on more that decade. But few data on its scalability have been published. In 2010-2011, Merck Serono Biodevelopment performed a study in order to evaluate the performance of several disposable bioreactors. As different techn...

the growth rate of stem cells in mobius cellready 3l bioreactor has been studied using comsol multi-physics simulation software in order to find out the best operational parameters for secure cell growth. the bioreactor geometry was defined according to the emd millipore issued information while turbulent and unsteady state solid-liquid 2-phase fluid flow equations were used for modelling the b...

 An equation-oriented approach was developed for steady state flowsheeting of a commercial methanol plant. The loop consists of fixed bed reactor, flash separator, preheater, coolers, and compressor. For steady sate flowsheeting of the plant mathematical model of reactor and other units are needed. Reactor used in loop is a Lurgi type and its configuration is rather complex. Previously reactor ...

Abstract Therapeutic monoclonal antibodies (mAbs) are typically manufactured using mammalian cell cultures in fed‐batch bioreactors, with increasing emphasis on meeting productivity and product quality attribute targets that depend strongly such process variables as nutrient feed rates bioreactor operating conditions. In this article, we identify, categorize, address the challenges of achieving...

Mixing has been one of the important parameters in characterizing and designing external air-lift bioreactors for the biological processes that require intensive mixing for mass transfer. In this study, pH tracer method was employed to characterize the mixing quality of a three-phase laboratory-scale external-loop air-lift bioreactor (EALR) used for cultivation of a pelletized filamentous funga...

A dissolved methane sensor based on silicone tube was designed, constructed and optimized.The silicone tube diameter, silicone tube length and helium flow rate (as the carrier gas(were considered as process parameters to be optimized.A continuous stream of helium (50 mL/min) was directed through the tubing, sweeping out the...

in this research, the effect of friction between the liquid metal and the sand mould wall and the effect of passage of liquid through a vertical bend and through a ceramic filter on the fluid flow and the melt velocity has been studied by measuring the velocity of the melt and direct observation of the liquid flow through the different parts of a naturally-pressurized running system. the fricti...