The developmental changes in glutamine synthetase activity in rat liver and brain have been studied and shown to be different in the two tissues. The liver enzyme exhibited a fall in activity after birth, followed by a slow recovery and a rapid increase in activity for a short interval of time, before a gradual rise to the adult level in about 40 days. The brain enzyme raised its activity gradu...

introduction in this study, we examined the effects of the antibiotics levofloxacin on the liver as well as its devastating effects which are ensued from its over-prescription. levofloxacin serves as one of the antibiotics of genitourinary system and inferior respiratory system. since liver is the foremost organ that receives all the materials absorbed by intestine through the portal vein, and ...

The behavior of ornithine carbamyl transferase activity (carbamylphosphate :1.-ornithine carbamyltransferase, EC 2.1 .3.3) was compared in proliferating normal liver (from developing rats and from partially hepatectomized rats) and in neoplastic liver (spectrum of hepatomas of different growth rates). The behavior of the liver enzyme in starved animals was also examined. The enzyme activity was...

Expression of mitochondrial dimethylglycine dehydrogenase (Me2GlyDH) was analysed in various tissues, liver cell types and developmental stages of the rat. Total RNA extracted from liver, spleen, brain, kidney, lung and heart was reverse-transcribed into cDNA and amplified with Me2GlyDH cDNA-specific oligonucleotides by PCR. Expression of the enzyme was observed mainly in liver and kidney. In a...

The concentration of phosphorylase in liver slices changes rapidly in response to certain experimental conditions (14). The concentration of phosphorylase in the cells represents a balance between inactivation of the enzyme and reactivation to the active form. Inactivation of liver phosphorylase is catalyzed by an enzyme formerly designated liver phosphorylase-inactivating enzyme. The synthetic...

In liver, the 470-residue bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2) catalyses the synthesis and degradation of fructose 2,6-bisphosphate, a potent stimulator of glycolysis. In rat hepatoma (HTC) cells, this enzyme has kinetic, antigenic, and regulatory properties, such as insensitivity to cyclic AMP-dependent protein kinase and lack of associated ...

Alcohol dehydrogenase (EC 1.1.1.1; alcohol:NAD+ oxidoreductase) activity varies 2-fold in liver extracts prepared from different inbred mouse strains. The strain-specific variation is not present in kidney extracts of male mice and is developmentally specific in the liver, occurring in mice 25 days of age and older. Neither electrophoretic nor heat lability properties of the enzyme from 15-day-...