Sows that had had 3 previous litters were fed either a diet with no added fat (low fat) which was rich in linoleic acid (56.7% 18:2n-6), or a high fat diet containing lard, high in total saturates (28.9%) and oleic acid (37.8% 18:1n-9) during gestation. Backfat build-up in the sows on the high fat diet was accelerated compared to the low fat group. On day 110 of gestation, fetuses were removed....

forty eight 8-month-old male goats were divided into three groups. in each group, eight goats were feedrestricted for 45, 60 or 75 days, and eight goats served as the control. restricted groups were fed with a maintenance ration, and the control goats were fed with a ration supporting 50 g of daily weight gain. at the end of restriction period, the restricted goats were offered the same ration ...

OBJECTIVES To investigate changes in the fat content of abdominal compartments and muscle area during weight loss using confounder-adjusted chemical-shift-encoded magnetic resonance imaging (MRI) in overweight diabetics. METHODS Twenty-nine obese diabetics (10/19 men/women, median age: 59.0 years, median body mass index (BMI): 34.0 kg/m2) prospectively joined a standardized 15-week weight-los...

BACKGROUND This study aimed to investigate the pathophysiology of hepatic microcirculatory dysfunction in non-alcoholic fatty liver disease (NAFLD). METHODS In Wistar rats, NAFLD model was induced by 20 weeks of high-fat diet (HFD) feeding. Rolling and adhesion of leukocytes and tissue perfusion in hepatic microcirculation were examined using in vivo microscopic and laser speckle contrast ima...

OBJECTIVE To investigate the relationship between hepatic fat content, circulating triglyceride levels and aortic stiffness in adult and childhood obesity. APPROACH AND RESULTS Seventy-seven adults and 18 children across a wide range of body mass index (18.5-52.6 kg/m(2); percentile 8-100) with no identifiable cardiac risk factors underwent; 1H- magnetic resonance spectroscopy to quantify hep...

Lipolysis may regulate liver free fatty acid (FFA) uptake and triglyceride accumulation; both are potential causes of insulin resistance and liver damage. We evaluated whether 1) systemic FFA release is the major determinant of liver FFA uptake in fasting humans in vivo and 2) the beneficial metabolic effects of FFA lowering can be explained by a reduction in liver triglyceride content. Sixteen...

Relationships among plasma lipoprotein cholesterol, cholesterol secretion by the isolated, perfused liver, and coronary artery atherosclerosis were examined in African green monkeys fed diets containing cholesterol and 35% of calories as fat enriched in polyunsaturated, monounsaturated, or saturated fatty acids. The livers of animals fed monounsaturated fat had significantly higher cholesteryl ...

The effect of dietary composition on cholesterol formation in the liver of alloxan diabetic rats was studied. Cholesterol formation in these ani mals was maintained at a subnormal level when the diet had a high content of simple sugar (sucrose, glucose or fructose) without fat, but was severely impaired with diets of all other compositions tested . The possible mechanism of maintenance of hepat...

BACKGROUND Nonalcoholic fatty liver disease has emerged as a novel cardiovascular risk factor. The aim of the study was to assess the effect of different ectopic fat depots on left ventricular (LV) function in subjects with nonalcoholic fatty liver disease. METHODS AND RESULTS Myocardial and hepatic triglyceride contents were measured with 1.5 T magnetic resonance spectroscopy and LV function...