نتایج جستجو برای: liver necrosis
تعداد نتایج: 409499 فیلتر نتایج به سال:
Background and Aims: Acetaminophen is a common anti-analgesic and antipyretic medication that in high doses leads to liver and kidney necrosis in humans and animals. Phlomis cancellata, from the mint family, is a plant that has antioxidant properties. In the present study, the hepatoprotective effect of Phlomis cancellata hydroalcoholic extract on acetaminophen-induced hepatotoxicity in rats wa...
INTRODUCTION The liver has inherent regenerative capacity via mitotic division of mature hepatocytes or, when the hepatic loss is massive or hepatocyte proliferation is impaired, through activation of hepatic stem/progenitor cells (HSPC). The dramatic clinical course of acute liver failure (ALF) has posed major limitations to investigating the molecular mechanisms of liver regeneration and the ...
The relative difficulty with which the characteristic central lobular liver necrosis can be produced in young pups after chloroform administration is in some way referable to the high glycogen contents of their livers. Evidence for this conclusion lies in the following facts: 1. Pups can readily be made to show the central liver necrosis which is found in chloroform poisoning in adults, if, pri...
Free cholesterol has been considered to be a critical risk factor of nonalcoholic fatty liver disease (NAFLD). It remains unknown whether dietary intake condensed tannins (CTs) have distinguishable effects alleviate damage caused by high diet. Male C57BL/6 mice were fed diet for 6 weeks, and given CTs treatment at dosage 200 mg/(kg·bw·day) the same time. The results indicated that compared with...
Through the intravenous injection of various substances differing very much in character, multiple necrosis can be produced in the liver of the guinea pig. In the mouse the effect of these substances is absent or much less marked. Different substances seem to differ, however, in their power to produce necrosis. In control animals necrosis in the liver is much more rare. It is found especially i...
OBJECTIVES Acetaminophen (APAP) overdose may cause acute liver injury. Ozone therapy (OT) is shown to reduce inflammation and necrosis in several entities. Thus, we have designed this study to evaluate the efficacy of OT in a rat model of APAP-induced liver injury. METHODS Twenty-seven Sprague-Dawley rats were divided into three groups: sham, APAP and APAP+OT groups. In the APAP and the APAP+...
Background: Extend of lung injury, inflammation due to SARS COV-2 can also cause liver injury. Liver injury in COVID-19 patients be caused by the direct effect on liver, cholangiocyte role, activation immune system, drug-induced and hypoxic Hepatocyte necrosis could increase transaminase. Therefore, transaminase may reveal severity. Aim: This study aims know relationship severity mortality pati...
Transmission of Toxocara vitulorum Infection causes a decrease in livestock productivity and results various types diseases humans. Chickens are one the parasitic hosts toxocariasis which has potential for transmission to The main location affected by T. larval infection is liver. current study aimed analyze description histopathological changes liver broiler chickens infected L2 vitulorum. pre...
Background and Aims: Adenovector gene transfer induces inflammatory response that finally leads to vector removal from delivered site. The effect of hydrodynamic pre-injection on Adenovector mediated liver inflammation remained elusive. Materials and Methods: Different mice groups were pre-treated by hydrodynamic saline, dexamethasone or nothing prior to Adeno-Luciferase administration. Their s...
Objective(s): Interleukin-36 receptor antagonist (IL-36Ra) is a new member of the IL-1 family that exhibits anti-inflammatory activity in a variety of inflammatory and immune diseases. Our purpose was to determine the effect of IL-36Ra on liver injury in a mouse hepatitis model induced by concanavalin A (ConA). Materials and Methods: Mic...
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