Background/Aims: We investigated the risk of abdominal operation in patients with fatty liver and the risk of any cancer in first-degree relatives of patients with fatty liver. Materials and Methods: We evaluated 105 patients with nonalcoholic fatty liver disease (NAFLD), 121 patients with biopsy-proven hepatitis C (61 patients with fatty liver and 60 patients without fatty liver), 50 patients ...

OBJECTIVE Prior studies on the association of physical activity (PA) and nonalcoholic fatty liver disease are limited by reliance on subjective measures of PA. We examined the association between objectively measured PA and hepatic steatosis defined by computed tomography (CT). METHODS We conducted a cross-sectional study of 1,060 Framingham Heart Study participants who participated in the Mu...

conclusions it seems that surrogate liver function tests and adipocytokine levels were correlated with the histologic findings of the liver. objectives the aim of the study was to evaluate the correlation between serum adipocytokines and the histologic findings of the liver in patients with non-alcoholic fatty liver disease (nafld). patients and methods this case-control study was performed on ...

conclusions twelve weeks of two grams of ginger supplementation showed beneficial effects on some nafld characteristics. further studies are recommended to assess the long-term supplementation effects. results ginger supplementation resulted in a significant reduction in alanine aminotransferase, γ-glutamyl transferase, inflammatory cytokines, as well as the insulin resistance index and hepatic...

Chronic liver disease is a major cause of morbidity and mortality worldwide and usually develops over many years, as a result of chronic inflammation and scarring, resulting in end-stage liver disease and its complications. The progression of disease is characterised by ongoing inflammation and consequent fibrosis, although hepatic steatosis is increasingly being recognised as an important path...

Introduction Fatty liver diseases or steatosis are increasingly common as a result of the obesity and diabetes epidemics. Asymptomatic, it can often lead to more severe diseases like fibrosis or cancer (1). The gold standard method to detect steatosis is the visual histopathological analysis of a liver sample collected by biopsy but the procedure is both invasive and painful and presents some r...

28 Glial cell line derived neurotrophic factor (GDNF) protects against high fat diet (HFD)-induced hepatic 29 steatosis in mice, however, the mechanisms involved are not known. In this study we investigated the effects of 30 GDNF overexpression and nanoparticle delivery of GDNF in mice on hepatic steatosis and fibrosis and the 31 expression of genes involved in the regulation of hepatic lipid u...

Exendin-4 (Ex-4), a glucagon-like peptide-1 receptor (GLP-1R) agonist, has been known to reverse hepatic steatosis in ob/ob mice. Although many studies have evaluated molecular targets of Ex-4, its mechanism of action on hepatic steatosis and fibrosis has not fully been determined. In the liver, glucose transporter 4 (GLUT4) is mainly expressed in hepatocytes, endothelial cells and hepatic stel...

Hepatic steatosis is defined when the deposition of triglyceride (TG) as lipid droplets in the cytoplasm of hepatocytes in more than 5% of hepatocytes. TG is a preferred storage nutrient as it provide greater caloric density (9 kcal/g) than do carbohydrates (4.5 kcal/g) or protein (4 kcal/g), and is insoluble in water, so they can accumulate to high levels with no adverse osmotic or colloidal e...

The metabolic syndrome X, characterized by insulin resistance, dyslipidemia, hypertension, and a male, visceral distribution of adipose tissue, is associated with increased morbidity and mortality from several prevalent diseases, such as diabetes, cancers, myocardial infarction, and stroke. Because the liver has a central role in carbohydrate, lipid, and steroid metabolism, we investigated the ...