Abstract Background Liver injuries have been reported in patients with coronavirus disease 2019 (COVID-19). This study aimed to investigate the clinical role played by severe acute respiratory syndrome 2 (SARS-CoV-2). Methods In this multicentre, retrospective study, parameters of liver function tests COVID-19 inpatients were compared between various time-points reference SARS-CoV-2 shedding, a...

Objective It is a great challenge to absorb and conduct biophysicochemical interactions at the nano-bio interface. Peptides are emerging as versatile materials whose function can be programmed to perform specific tasks. Peptides combined nanoparticles might be utilized as a new approach of treatment. Human β-defensin 3 (hBD3), possesses both antimicrobial and proregeneration properties. Gold na...

BACKGROUND High levels of alkaline phosphatase (ALP) have been associated with increased mortality in patients with advanced chronic kidney disease (CKD). We hypothesize that elevated ALP could be partly explained by subclinical liver congestion related to left ventricular diastolic dysfunction. METHODS Doppler echocardiography was performed in 68 patients with advanced CKD followed up for a ...

We investigated the prevalence and characteristics of intestinal alkaline phosphatase (ALP; EC 3.1.3.1) identified in human serum by cellulose acetate electrophoresis in 8% of fasting serum samples from hospital patients (n = 500) and in 35% of fasting serum samples from patients with diabetes mellitus (n = 106; not differentiated between types 1 and 2). The intestinal ALP electrophoretic band ...

Background: Diabetes mellitus, a group of metabolic disorder with multiple etiologies is characterized by chronic hyperglycaemia, induced deficiency insulin production and action. Prediabetes type hyperglycemia in which glycemic indices are higher than normal but lower the diabetes threshold. Objective: This study aims to assess impact bone markers (serum calcium, phosphorus alkaline phosphatas...

in this study 110 samples of amniotic fluid of sheep at different stage of pregnancy were assessed for creatinine (cr), alkaline phosphatase (alp), aspartate aminotransferase (ast), creatin kinase (ck), lactate dehydrogenase (ldh) and arginase. significant increase (p

A series of novel nanocomposites containing graphene oxide (GO) suitable for stereolithography is presented. Different loads GO are tested, identifying that these materials can be printed with concentrations up to 2.5 wt% GO, presenting improved mechanical properties below 1.0 GO. In this range, the exhibit higher strength and toughness when compared pristine resin. Microscopic analyses materia...

The objective of this study was to investigate aspartate-amino-transferase (AST), γ-glutamyl-transferase(GGT), alkaline phosphatase (ALP), lactate-dehydrogenase (LDH) and acid phosphatase (AcP) activities andsemen parameters (volume, pH, concentration, total sperm number (TSN), progressive motility, dead sperm,total morphological defect (TMD) and hypo-osmotic swelling test (HOST)) in seminal pl...

Serum alkaline phosphatase (ALP) isoenzymes were studied in normal dogs using a commercially available polyacrylamide gel disk electrophoresis kit (PAG/disk kit). Serum samples taken from the dogs were incubated with neuraminidase, after which most showed ALP isoenzymes as two characteristic stained bands. To determine the origin of each band, ALP isoenzymes of serum and tissue extracts (liver,...

Transport of yeast alkaline phosphatase (ALP) to the vacuole depends on the clathrin adaptor-like complex AP-3, but does not depend on proteins necessary for transport through pre-vacuolar endosomes. We have identified ALP sequences that direct sorting into the AP-3-dependent pathway using chimeric proteins containing residues from the ALP cytoplasmic domain fused to sequences from a Golgi-loca...