PURPOSE The standard radiation dose for patients with locally rectal cancer treated with preoperative chemoradiotherapy is 45-50 Gy in 25-28 fractions. We aimed to assess whether a difference exists within this dose fractionation range. MATERIALS AND METHODS A retrospective analysis was performed to compare three dose fractionation schedules. Patients received 50 Gy in 25 fractions (group A),...

OBJECTIVES/HYPOTHESIS This study aims to evaluate the pattern of nodal metastasis to level V in parotid cancer and to examine the clinical value of level V neck dissection (LVND). STUDY DESIGN Retrospective cohort study. METHODS Retrospective chart review of 86 patients (47 N0 nodal metastasis [N0] neck and 39 positive nodal metastasis [N(+) ] neck) who received parotidectomy and neck disse...

Radionuclide therapy is widely used as an effective modality in the management of bone pain. The main indication for this treatment is symptomatic bone metastases, confirmed by bone scintigraphy. We present a case of small cell lung cancer (SCLC) stage T4N2M1b, with a good metabolic response to systemic therapy and radiotherapy of the primary tumor and locoregional disease, which became metabol...

Abstract Cutaneous squamous cell carcinoma (cSCC) is a keratinocyte tumour with inherent metastatic potential. Approximately 4% of cSCCs metastasize locoregionally and/or distally. Mohs micrographic surgery (MMS) efficacious, cure rates in selected cases 95–99%. Diagnoses cSCC treated at St James’s Hospital between the years 2010 and 2019 were identified via histopathology reports. Clinicopatho...

Introduction. Primary sarcomas are uncommonly seen in the larynx and comprise around 1% of all laryngeal malignant tumors. We present three cases patients with different types discuss about diagnostic treatment difficulties. Case outline. Each patient presented hoarseness shortness breath. Computed tomography scans showed large transglottic tumors no signs cervical lymphadenopathy definitive di...

INTRODUCTION Colorectal cancer most commonly metastasizes to the regional lymph nodes, liver, bone, lung, and brain. Metastases to mediastinal lymph nodes is a rare entity which has never been reported to be solitary. CASE REPORT We herein describe a 67-year-old male patient with a solitary mediastinal lymph node metastasis three years following the resection of his primary rectosigmoid carci...

Introduction: Recurrent disease following colorectal cancer surgery will occur in about 30-50% of patients when considering both locoregional relapse and distant metastasis. For patients with rectal cancer, preoperative chemoradiotherapy followed by TME can provide durable 10-years overall survival (OS) of 58% and recurrence-free survival (RFS) of 62%. Background: Despite optimal treatment with...

The majority of locoregional recurrences in melanoma occur in the form of intradermal or subcutaneous local or in-transit metastasis. In-transit melanoma represents contamination of the lymphatic space that, if treated, can result in long-term cure in a subset of patients. The management of in-transit metastases is challenging, since the treatments and extent of disease vary greatly based on th...

A randomized trial was conducted at the Institut Gustave-Roussy (IGR) between 1972 and 1980 comparing tumorectomy and breast irradiation with modified radical mastectomy. One hundred and seventy-nine patients with an infiltrating breast carcinoma up to 20 mm in diameter at macroscopic examination were included: 88 had conservative management, and 91 a mastectomy. All patients had a low-axillary...