Objective-Effect of local administration of laminin and fibronectin on nerve regeneration was assessed. Design- Experimental study. Animal- Sixty male Wistar rats. Procedures- The animals were divided into four experimental groups (n=15), randomly: In transected group left sciatic nerve was transected and stumps were fixed in adjacent muscle. In treatment group (CHIT/LF) the defect was bridg...

1. introduction some narratologists like kristeva and genette believe that if a text remembers another text, a dialogue has taken place between them and an inter-textual (or trans-textual) relationship has thus been established. some also believe that there is always a relationship between texts. among them, genette accompanied his claims by a theory and opened a new way before the narratologis...

Anisotropic orientation and accurate positioning of neural cells is achieved by patterning stripes of the extracellular matrix protein laminin on the surface of polystyrene tissue culture dishes by micromoulding in capillaries (MIMICs). Laminin concentration decreases from the entrance of the channels in contact with the reservoir towards the end. Immunofluorescence analysis of laminin shows a ...

Laminin self-assembles into large polymers by a cooperative two-step calcium-dependent mechanism (Yurchenco, P. D., E. C. Tsilibary, A. S. Charonis, and H. Furthmayr. 1985. J. Biol. Chem. 260:7636-7644). The domain specificity of this process was investigated using defined proteolytically generated fragments corresponding to the NH2-terminal globule and adjacent stem of the short arm of the B1 ...

Plasmin is converted from its zymogen plasminogen by tissue type or urokinase type plasminogen activator (PA) and degrades many components of the extracellular matrix (ECM). To explore the possibility that the PA-plasmin system regulates synaptic plasticity, we investigated the effect of plasmin on degradation of ECM and synaptic plasticity by using organotypic hippocampal cultures. High-freque...

In linear IgA bullous dermatosis (LABD) caused by IgA-class autoantibodies against proteins in the basement membrane zone (BMZ), IgG deposition along BMZ can be observed, and such cases have been recently referred to as IgA/IgG (LAGBD). Our patient presented with a history of oral nasopharyngeal ulcers followed development tense bullae over chest, back extremities, arranged an annular pattern c...