The key characteristic of a clinical researcher is probably the determination to deliver high quality studies despite all the inevitable bumps along the road. As well as the difficulties around funding and maintaining large collaborations that can deliver high impact multicentre studies, there are also more worrying challenges that threaten the robustness of the science. Some are widely recogni...

A variety of mechanotransduction pathways mediate the response of fibroblasts or chondrocytes to ultrasound stimulation. In addition, regulatory pathways that co-ordinate stimulus-specific cellular responses are likely to exist. In this study, analysis was confined to the hypothesis that ultrasound stimulation (US) influences the chromatin structure, and that these changes may reflect a regulat...

In vivo feasibility of using low-intensity focused ultrasound (FUS) to transiently modulate the function of regional brain tissue has been recently tested in anesthetized lagomorphs [1] and rodents [2-4]. Hypothetically, ultrasonic stimulation of the brain possesses several advantages [5]: it does not necessitate surgery or genetic alteration but could ultimately confer spatial resolutions supe...

MRI-guided Low Intensity Focused Ultrasound has a wide range of applications in neurological disorders and is superior to other minimally invasive neuromodulation techniques terms better spatial resolution stimulating deeper brain structures. Parkinson’s disease, Alzheimer’s essential tremor, malignancy, epilepsy, nerve block, medication delivery, stroke are among the which benefit from Low-Int...