Oral absorption of compounds depends on many physiological, physiochemical and formulation factors. Two important properties that govern oral absorption are in vitro permeability and solubility, which are commonly used as indicators of human intestinal absorption. Despite this, the nature and exact characteristics of the relationship between these parameters are not well understood. In this stu...

Variations in apparent diffusion coefficient of water (ADC) and blood-brain barrier (BBB) permeability after ischemia have been suggested, though the correlation between ADC alterations and BBB opening remains to be studied. We hypothesized that there are correlations between the alteration of ADC and BBB permeability. Rats were subjected to 2 h of transient middle cerebral artery occlusion and...

In unconfined parts of the Chalk aquifer in southeast England, permeability generally varies laterally with the lowest permeabilities occurring beneath interfluve areas, and the highest beneath river valleys and dry valleys. Furthermore, the Chalk in the river valleys is normally in excellent hydraulic continuity with the overlying highly permeable Quaternary gravels. However, recent field inve...

Proton exchange membranes (PEM) for a direct methanol fuel cell (DMFC) have main drawbacks which are methanol permeability, reduced proton conductivity and the cost of the membrane. This paper reviews different polymeric materials such as fluorinated, non-fluorinated, acid-base complex, and composite membranes for DMFC. Currently, nonfluorinated membranes gain a lot of atte...

As a method to reduce atmospheric emissions of carbon dioxide (CO2), this greenhouse gas can be separated at large point-sources, compressed and injected into geological formations such as saline aquifers. Several physical features of the fluids and the rock sequester the CO2 in the pores of the rock for geologic time-scales. One such feature is dissolution into the brine, which increases the d...

Skin permeability is widely considered to be mechanistically implicated in chemically-induced skin sensitization. Although many chemicals have been identified as skin sensitizers, there have been very few reports analyzing the relationships between molecular structure and skin permeability of sensitizers and non-sensitizers. The goals of this study were to: (i) compile, curate, and integrate th...