Endotoxin lipopolysaccharide (LPS) is the most powerful and effective immunostimulant key virulence factor produced by Escherichia coli (E. coli) accountable for many of inflammatory changes observed during bovine mastitis. In this study, whole-transcriptomic gene in peripheral blood mononuclear cells (PBMCs) stimulated with LPS were compared to control group analyzed RNA sequencing. A total 35...

There is growing interest in flavonoids for their wide array of biological actions. In neurodegenerative disorders these naturally occurring polyphenolic compounds, are known to inhibit proinflammatory mediators such as in TNF–? and IL-6 in lipopolysaccharide (LPS) stimulated neuronal degeneration, which are associated with Alzheimer’s and Parkinson’s disease. Recent studies on flavonoids have ...

Objective: There is evidence that gestational exposure to lipopolysaccharide (LPS) results in fetal zinc deficiency, and eventually neurodevelopmental abnormalities. In this study, we utilized a rat model of maternal immune activation (MIA) to investigate the possible neuroprotective effect of zinc supplementation throughout pregnancy on hippocampal astrocytes activation as well as inflammatory...

The South Asian summer monsoon brings copious rain to agriculture-dependent country India and bulk of the precipitation in central is attributed low pressure systems (LPS). Large uncertainty exists statistics LPS during historical period future projections. In this study, we have developed an tracking approach which considers geopotential height anomaly relative vorticity thresholds. validated ...

To investigate the effects of carvacrol supplementation in rainbow trout induced by lipopolysaccharide (LPS), relative gene expressions levels of some pro-inflammatory cytokines and apoptosis markers in kidney and liver were measured. Fish with a mean weight of 44.71±1.33 g were studied using four different treatments with three replicates each. Inflammation and apoptosis were performed using L...

Objective: In cardiovascular diseases, inflammatory response plays an important role and affects heart function. As a flavonoid compound, p-coumaric acid (pCA), commonly exists in many fruits and vegetables and has a therapeutic effect on inflammatory diseases due to its anti-inflammatory properties. The purpose of the present study was to investigate pCA anti-inflammatory effect and the miRNAs...

Cytokine storm is one of the leading causes death in patients with COVID‑19. Metformin has been shown to inhibit action a wide range proinflammatory cytokines such as IL‑6, and TNF‑α which may ultimately affect cytokine due Covid‑19. The present study analyzed anti‑inflammatory effect oral intraperitoneal (IP) metformin administration routes mouse model lipopolysaccharide (LPS)‑induced storm. A...

background : propylene glycol (1,2-propanediol, pg) is a commonly used solvent for oral, intravenous, as well as topical pharmaceutical preparations. while pg is generally considered to be safe, it has been known that large intravenous doses given over a short period of time can be toxic. objective: to evaluate the effect of pg in sepsis induced by the bacterial endotoxin lipopolysaccharide (lp...

the inhibition of the inducible nitric oxide synthase (inos), cyclooxygenase 2 (cox-2) and nuclear factor-κb (nf-κb) production are research targets of attract in the field of anti-inflammatory drug development. therefore, this study was designed to investigate the anti-inflammatory effects of novel thiazolidinone derivatives using a cellular model of lipopolysaccharide (lps)-stimulated murine ...