During embryonic development in vertebrates, left-right (L/R) asymmetry is reliably generated by a conserved mechanism: a L/R asymmetric signal is transmitted from the embryonic node to other parts of the embryo by the L/R asymmetric expression and diffusion of the TGF-β related proteins Nodal and Lefty via propagating gene expression fronts in the lateral plate mesoderm (LPM) and midline. In z...

A two-stage latent prosody model-language model (LPM-LM)-based approach is proposed to identify two Mandarin accent types spoken by native speakers in Mainland China and Taiwan. The frontend LPM tokenizes and jointly models the affections of speaker, tone and prosody state of an utterance. The backend LM takes the decoded prosody state sequences and builds n-grams to model the prosodic differen...

Capacitive Micro-machined Ultrasonic Transducers (CMUTs) are the ultrasonic devices which produce better features in contrast to piezoelectric transducers. The intrinsic parameter of CMUT varies with the variation in geometrical dimension of the device. The cavity height and the radius of the CMUT with circular membrane is varied in the lumped parallel plate model for its impact on the paramete...

Simple, lumped-parameter musculoskeletal models may be more adaptable and practical for clinical real-time control applications, such as prosthesis control. In this study, we determined whether a lumped-parameter, EMG-driven musculoskeletal model with four muscles could predict wrist and metacarpophalangeal (MCP) joint flexion/extension. Forearm EMG signals and joint kinematics were collected s...

The preferred vascular access for hemodialysis is an autologous arteriovenous fistula (AVF) in the arm: a surgically created connection between an artery and vein. The surgeon selects the AVF location based on experience and preoperative diagnostics. However, 20-50% of all lower arm AVFs are hampered by a too low access flow, whereas complications associated with too high flows are observed in ...

The aim of the project was to assemble two optimum solid lipid nanoparticle (SLN) formulations for oral delivery of loperamide (LPM) to treat different types of diarrhea, and to evaluate their release profiles in vitro and pharmacokinetic properties in vivo. In this work, glyceryl trimyristate (Dynasan 114) nanoparticles containing the drug LPM and sodium cholate as a stabilizer were prepared u...